Babir Fiona J, Islam Hashim, McCreary Sara, Vaz Erica, Falkenhain Kaja, Cranston Kaela, Jung Mary, Singer Joel, Sandilands Roderick, Marcotte-Chénard Alexis, Stamatakis Emmanuel, Richards Douglas L, Gibala Martin J, Little Jonathan P
Department of Kinesiology, McMaster University, Hamilton, Ontario, Canada.
School of Health and Exercise Sciences, The University of British Columbia - Okanagan, Kelowna, British Columbia, Canada.
Scand J Med Sci Sports. 2025 Aug;35(8):e70117. doi: 10.1111/sms.70117.
This randomized controlled trial investigated the feasibility and efficacy of a 12-week remotely delivered exercise snacks intervention in the real world. Inactive adults (n = 77; 56 females, 21 males; mean age ± SD: 54 ± 6 years, mean VO ± SD: 24.5 ± 4.4 mL/kg/min) were randomized to an exercise snacks (n = 38; bodyweight exercises) or a placebo exercise control group (n = 39; stretching exercises). Participants were encouraged to perform ≥ 3 exercise bouts/day (bouts were ≤ 1 min), ≥ 3 days/week delivered through an online platform. Feasibility outcomes included exercise adherence and enjoyment. The primary efficacy outcome was peak oxygen uptake (VO) at baseline and 12 weeks. Secondary outcomes included rating of perceived exertion (RPE; 0-10 scale), exercise enjoyment scale (EES; 0-7), and blood biomarkers of cardiometabolic health. Seventy-three participants completed the intervention and 71 completed at least one follow-up testing measure. Adherence, based on total bouts from the online platform, exceeded the prescribed minimum and was not different between the exercise snacks (173 ± 74) and control (158 ± 92) groups (p = 0.37). RPE across the intervention was higher in the exercise snacks compared to the control group (3.0 ± 0.7 vs. 2.1 ± 0.6, respectively; p < 0.001) with high enjoyment (both groups averaging ~4.2 ± 0.9; p > 0.05). There were no between-group differences in the change in absolute (mean difference: 0.0 [95% CI: -0.1, 0.1] L/min) or relative (0.4 [-0.6, 1.4] mL/kg/min) VO (p > 0.05). There were no differences in blood biomarkers of cardiometabolic health (p > 0.05). Twelve weeks of remotely delivered exercise snacks were feasible for inactive adults to complete in the real world. Future work may need to optimize the exercise snacks stimulus to elicit physiological changes. Trial Registration: ClinicalTrials.gov identifier: NCT05574426.
这项随机对照试验研究了在现实世界中进行为期12周的远程提供的运动零食干预的可行性和有效性。不活跃的成年人（n = 77；56名女性，21名男性；平均年龄±标准差：54±6岁，平均VO₂max±标准差：24.5±4.4 mL/kg/min）被随机分为运动零食组（n = 38；进行体重训练）或安慰剂运动对照组（n = 39；进行伸展运动）。鼓励参与者每天进行≥3次运动回合（每次回合≤1分钟），每周≥3天，通过在线平台进行。可行性结果包括运动依从性和运动乐趣。主要疗效结果是基线和12周时的峰值摄氧量（VO₂max）。次要结果包括主观用力程度分级（RPE；0 - 10级）、运动乐趣量表（EES；0 - 7）以及心脏代谢健康的血液生物标志物。73名参与者完成了干预，71名完成了至少一项随访测试指标。基于在线平台的总回合数计算的依从性超过了规定的最小值，运动零食组（173±74）和对照组（158±92）之间没有差异（p = 0.37）。与对照组相比，运动零食组在整个干预过程中的RPE更高（分别为3.0±0.7和2.1±0.6；p < 0.001），且运动乐趣都很高（两组平均约为4.2±0.9；p > 0.05）。绝对VO₂max（平均差异：0.0 [95%置信区间：-0.1, 0.1] L/min）或相对VO₂max（0.4 [-0.6, 1.4] mL/kg/min）的变化在组间没有差异（p > 0.05）。心脏代谢健康的血液生物标志物也没有差异（p > 0.05）。对于不活跃的成年人来说，在现实世界中完成为期12周的远程提供的运动零食干预是可行的。未来的工作可能需要优化运动零食刺激以引发生理变化。试验注册：ClinicalTrials.gov标识符：NCT05574426。
