Golper T A, Wedel S K, Kaplan A A, Saad A M, Donta S T, Paganini E P
Int J Artif Organs. 1985 Nov;8(6):307-12.
We have discussed the basic principles of pharmacokinetics and convective solute removal in the context of each other. Clinical observations appear to follow the theoretical expectations. For practical purposes plasma and plasma water are not different. In the calculation of drug sieving, venous samples do not contribute enough to warrant their extra costs. We recommend that drug removal in hemofiltration be expressed by the sieving coefficient, UF/A. Drug sieving data in humans undergoing CAVH are tabulated. Recommendations for supplemental dosing are discussed which are applicable to any clinical setting.
我们已经在相互关联的背景下讨论了药代动力学和对流溶质清除的基本原理。临床观察结果似乎符合理论预期。出于实际目的，血浆和血浆水并无差异。在药物筛选的计算中，静脉血样本的作用不足以证明其额外成本的合理性。我们建议通过筛系数UF/A来表示血液滤过中的药物清除情况。列出了接受连续性动静脉血液滤过（CAVH）的患者的药物筛选数据。讨论了适用于任何临床情况的补充给药建议。
