Rogers Breanna J, Deng Yangyang, Moniruzzaman Mohammad, Tamura Kosuke
Socio-Spatial Determinants of Health (SSDH) Laboratory, Population and Community Health Sciences Branch, Division of Intramural Research, National Institute on Minority Health and Health Disparities, National Institutes of Health, Bethesda, 20892, MD, USA.
Community Ment Health J. 2025 Aug 7. doi: 10.1007/s10597-025-01500-w.
Major depressive disorder (MDD) is a serious public health concern in the United States. Prior research has shown that neighborhood characteristics serve as protective factors against depression in adolescents. Few studies have examined the association between perceived neighborhood characteristics and depression during middle and older adulthood. We examined the association between each perceived neighborhood social environment (i.e., social cohesion and safety) and the presence of MDD among Midlife in the United States III (MIDUS) participants (n = 2,435, mean age = 63.6 years, Female = 54.4%). Moreover, we investigated whether these associations were moderated by sex and income, separately. All models were adjusted for demographic variables. Overall, perceived neighborhood social cohesion and safety were negatively associated with the presence of MDD. The associations varied when analyses were stratified by sex and income. Findings offer support for the perceived neighborhood social environments as protective factors against depression during middle and older adulthood.
重度抑郁症（MDD）是美国一个严重的公共卫生问题。先前的研究表明，邻里特征是青少年抑郁症的保护因素。很少有研究探讨中年和老年期感知到的邻里特征与抑郁症之间的关联。我们在美国中年人群三期（MIDUS）参与者（n = 2435，平均年龄 = 63.6岁，女性 = 54.4%）中，研究了每种感知到的邻里社会环境（即社会凝聚力和安全性）与MDD存在之间的关联。此外，我们分别研究了这些关联是否受到性别和收入的调节。所有模型均对人口统计学变量进行了调整。总体而言，感知到的邻里社会凝聚力和安全性与MDD的存在呈负相关。按性别和收入分层分析时，这些关联有所不同。研究结果支持将感知到的邻里社会环境作为中年和老年期抑郁症的保护因素。
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