Jiang Yuchao, Ou Dejin, Huang Jinzhu, Huang Si, Lin Yuhui, Huang Jionghua
Department of Cardiovascular Medicine, Guangdong Provincial Key Laboratory of Major Obstetric Diseases, Guangdong Provincial Clinical Research Center for Obstetrics and Gynecology, The Third Affiliated Hospital, Guangzhou Medical University, Guangzhou, 510150, China.
Department of Clinical Laboratory Medicine, Guangdong Provincial Key Laboratory of Major Obstetric Diseases, Guangdong Provincial Clinical Research Center for Obstetrics and Gynecology, The Third Affiliated Hospital, Guangzhou Medical University, Guangzhou, 510150, China.
Sci Rep. 2025 Aug 7;15(1):28877. doi: 10.1038/s41598-025-07545-x.
Trim24 has been implicated in inflammatory processes and lipid metabolism, yet its role in atherosclerosis (AS) remains insufficiently explored. This study aimed to evaluate the diagnostic value of serum Trim24 in AS and its association with disease severity. This prospective case-control study included 137 AS patients and 137 healthy controls. Serum Trim24 and sCD163 levels were measured using ELISA. Clinical characteristics, including lipid profiles, inflammatory markers, and the Gensini score, were collected. Univariate and multivariate logistic regression analyses were performed to identify independent risk factors for AS, severe AS, and severe stenosis. Receiver operating characteristic (ROC) curve analysis was employed to evaluate the diagnostic performance of Trim24. Serum Trim24 levels were significantly higher in AS patients compared to healthy controls. Within the AS group, Trim24 levels were higher in patients with severe AS and severe stenosis compared to their non-severe counterparts. Trim24 exhibited strong diagnostic performance for AS (AUC = 0.928), severe AS (AUC = 0.826), and severe stenosis (AUC = 0.928). Additionally, sCD163 levels were significantly lower in AS patients, especially in those with high Trim24 expression, severe AS, and severe stenosis. ROC analysis showed moderate diagnostic value of sCD163 for AS and its severity (AUC = 0.708-0.778). Curve Estimation revealed a negative correlation between Trim24 and sCD163. Multivariate logistic regression identified Trim24 was an independent risk factors for AS, severe AS, and severe stenosis, respectively. Elevated serum Trim24 levels are associated with increased AS risk and severity, likely through modulation of macrophage polarization. Trim24 demonstrates strong potential as a diagnostic biomarker for AS and its progression, supporting further investigation in larger, more diverse populations.
Trim24已被证明与炎症过程和脂质代谢有关，但其在动脉粥样硬化（AS）中的作用仍未得到充分研究。本研究旨在评估血清Trim24在AS中的诊断价值及其与疾病严重程度的关系。这项前瞻性病例对照研究纳入了137例AS患者和137名健康对照。采用酶联免疫吸附测定法（ELISA）检测血清Trim24和sCD163水平。收集临床特征，包括血脂谱、炎症标志物和Gensini评分。进行单因素和多因素逻辑回归分析，以确定AS、重度AS和重度狭窄的独立危险因素。采用受试者工作特征（ROC）曲线分析来评估Trim24的诊断性能。与健康对照相比，AS患者的血清Trim24水平显著更高。在AS组中，重度AS和重度狭窄患者的Trim24水平高于非重度患者。Trim24对AS（AUC = 0.928）、重度AS（AUC = 0.826）和重度狭窄（AUC = 0.928）表现出强大的诊断性能。此外，AS患者的sCD163水平显著降低，尤其是在Trim24高表达、重度AS和重度狭窄的患者中。ROC分析显示sCD163对AS及其严重程度具有中等诊断价值（AUC = 0.708 - 0.778）。曲线估计显示Trim24与sCD163之间呈负相关。多因素逻辑回归确定Trim24分别是AS、重度AS和重度狭窄的独立危险因素。血清Trim24水平升高与AS风险和严重程度增加相关，可能是通过调节巨噬细胞极化实现的。Trim24作为AS及其进展的诊断生物标志物具有强大的潜力，支持在更大、更多样化的人群中进行进一步研究。
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