Mader D R, Conzelman G M, Baggot J D
J Am Vet Med Assoc. 1985 Dec 1;187(11):1134-6.
Eight gopher snakes were given amikacin (5 mg/kg of body weight IM) and were housed at ambient temperatures of 25 C or 37 C. Snakes housed at 37 C had a larger volume of distribution, and a more rapid body clearance of amikacin while the apparent half-life was not changed significantly. The minimum inhibitory concentrations of amikacin against isolated snake pathogens were determined at both temperatures. Bacteria were twice as sensitive at 37 C than at 25 C. The data indicated that amikacin should be given IM at a dose schedule of 5 mg/kg (loading dose) followed by 2.5 mg/kg every 72 hours, and that snakes should be housed near the high end of their preferred optimum ambient temperature during treatment.
给八条地鼠蛇注射阿米卡星（5毫克/千克体重，肌肉注射），并将它们饲养在25摄氏度或37摄氏度的环境温度下。饲养在37摄氏度的蛇，其阿米卡星的分布容积更大，体内清除速度更快，而表观半衰期没有显著变化。在这两个温度下都测定了阿米卡星对分离出的蛇病原体的最低抑菌浓度。细菌在37摄氏度时的敏感性是25摄氏度时的两倍。数据表明，阿米卡星应以5毫克/千克（负荷剂量）的剂量方案进行肌肉注射，随后每72小时注射2.5毫克/千克，并且在治疗期间蛇应饲养在其偏好的最佳环境温度范围的较高端附近。
