Clark C H, Rogers E D, Milton J L
Am J Vet Res. 1985 Dec;46(12):2654-7.
Plasma chloramphenicol concentrations after a subcutaneous injection were studied in 87 snakes of 16 different species. The biological half-life of chloramphenicol varied from 3.3 hours in the indigo snake (Drymarchon corais couperi) to 22.1 hours in the midland water snake (Nerodia sipedon). A single dosage of 50 mg of chloramphenicol/kg of body weight produced plasma concentrations greater than 5 micrograms/ml for nearly 72 hours in 2 species of water snakes (Nerodia erythrogaster, Nerodia sipedon), for 24 hours in the Burmese python (Python molurus bivittatus), and for less than 12 hours in the gray rat snake, Indigo snake, and eastern king snake (Elaphe obsoleta spiloides, Drymarchon coraise couperi, and Lampropeltis getulus getulus). A dosage of 50 mg/kg administered to water snakes every 72 hours for 18 days maintained a minimum plasma concentration of chloramphenicol between 2 and 5 micrograms/ml.
对16种不同蛇类的87条蛇进行了皮下注射后血浆氯霉素浓度的研究。氯霉素的生物半衰期在靛青蛇（Drymarchon corais couperi）中为3.3小时，在中部水蛇（Nerodia sipedon）中为22.1小时。单剂量50毫克氯霉素/千克体重在2种水蛇（红腹食蜗蛇Nerodia erythrogaster、中部水蛇Nerodia sipedon）中可使血浆浓度在近72小时内高于5微克/毫升，在缅甸蟒（Python molurus bivittatus）中可维持24小时，在灰鼠蛇、靛青蛇和东部王蛇（Elaphe obsoleta spiloides、Drymarchon coraise couperi和Lampropeltis getulus getulus）中则维持不到12小时。对水蛇每72小时给予50毫克/千克的剂量，持续18天，可使血浆氯霉素的最低浓度维持在2至5微克/毫升之间。
