Chen Kaichuan, Lyu Xiao, Liu Xin, Bi Yanlong, Wang Zhen
Department of Ophthalmology, Baoshan Branch, Ren Ji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China.
Department of Ophthalmology, Tongji Hospital, School of Medicine, Tongji University, Shanghai, China.
Front Med (Lausanne). 2025 Jul 24;12:1643137. doi: 10.3389/fmed.2025.1643137. eCollection 2025.
This paper reports a rare case of endogenous endophthalmitis caused by hemodialysis in end-stage renal disease (ESRD).
The patient was a 70-year-old female. The best-corrected visual acuity (BCVA) was light perception (LP). Endogenous endophthalmitis was diagnosed based on clinical manifestations and auxiliary examinations. Pathogenic microbial metagenomic detection of intraocular aqueous was used to identify . As multiple investigations showed no source of infection, a standardized treatment plan was proposed.
The treatment included the local application of antibiotics, glucocorticoids and cycloplegic drugs, vitrectomy, intravitreal injection of vancomycin and ceftazidime, anterior chamber irrigation, and systemic antibiotic treatment after the operation. After treatment, the inflammation subsided, and the BCVA at discharge was hand movement (HM).
Our study highlights the importance of rapid pathogenic microbial metagenomic detection and timely standardized intervention in the treatment of endogenous endophthalmitis.
本文报告一例终末期肾病（ESRD）血液透析所致罕见的内源性眼内炎病例。
患者为一名70岁女性。最佳矫正视力（BCVA）为光感（LP）。根据临床表现及辅助检查诊断为内源性眼内炎。采用眼内房水致病微生物宏基因组检测进行鉴定。由于多项检查未发现感染源，故提出标准化治疗方案。
治疗包括局部应用抗生素、糖皮质激素及睫状肌麻痹剂、玻璃体切除术、玻璃体内注射万古霉素和头孢他啶、前房冲洗以及术后全身应用抗生素治疗。治疗后炎症消退，出院时BCVA为手动（HM）。
我们的研究强调了快速致病微生物宏基因组检测及及时标准化干预在内源性眼内炎治疗中的重要性。
