Olaimat Amin N, Al-Holy Murad A, Shahbaz Hafiz M, Al-Nabulsi Anas A, Abu Ghoush Mahmoud H, Osaili Tareq M, Ayyash Mutamed M, Holley Richard A
Dept. of Clinical Nutrition and Dietetics, Faculty of Allied Health Sciences, Hashemite Univ., P.O. Box 150459, Zarqa, 13115, Jordan.
Dept. of Food Science and Human Nutrition, Univ. of Veterinary and Animal Sciences, Lahore, 54000, Pakistan.
Compr Rev Food Sci Food Saf. 2018 Sep;17(5):1277-1292. doi: 10.1111/1541-4337.12387. Epub 2018 Aug 9.
Listeria monocytogenes is an opportunistic pathogen that has been involved in several deadly illness outbreaks. Future outbreaks may be more difficult to manage because of the emergence of antibiotic resistance among L. monocytogenes strains isolated from food products. The present review summarizes the available evidence on the emergence of antibiotic resistance among L. monocytogenes strains isolated from food products and the possible ways this resistance has developed. Furthermore, the resistance of food L. monocytogenes isolates to antibiotics currently used in the treatment of human listeriosis such as penicillin, ampicillin, tetracycline, and gentamicin, has been documented. Acquisition of movable genetic elements is considered the major mechanism of antibiotic resistance development in L. monocytogenes. Efflux pumps have also been linked with resistance of L. monocytogenes to some antibiotics including fluoroquinolones. Some L. monocytogenes strains isolated from food products are intrinsically resistant to several antibiotics. However, factors in food processing chains and environments (from farm to table) including extensive or sub-inhibitory antibiotics use, horizontal gene transfer, exposure to environmental stresses, biofilm formation, and presence of persister cells play crucial roles in the development of antibiotic resistance by L. monocytogenes.
单核细胞增生李斯特菌是一种机会致病菌，曾引发多起致命疾病的爆发。由于从食品中分离出的单核细胞增生李斯特菌菌株出现了抗生素耐药性，未来的疫情爆发可能更难控制。本综述总结了从食品中分离出的单核细胞增生李斯特菌菌株抗生素耐药性出现的现有证据以及这种耐药性产生的可能方式。此外，已记录了食品中单核细胞增生李斯特菌分离株对目前用于治疗人类李斯特菌病的抗生素（如青霉素、氨苄青霉素、四环素和庆大霉素）的耐药情况。获得可移动遗传元件被认为是单核细胞增生李斯特菌抗生素耐药性产生的主要机制。外排泵也与单核细胞增生李斯特菌对包括氟喹诺酮类在内的某些抗生素的耐药性有关。从食品中分离出的一些单核细胞增生李斯特菌菌株对多种抗生素具有固有耐药性。然而，食品加工链和环境（从农场到餐桌）中的因素，包括广泛或亚抑制性抗生素的使用、水平基因转移、暴露于环境压力、生物膜形成和持留细胞的存在，在单核细胞增生李斯特菌抗生素耐药性的发展中起着关键作用。
