Du Hui, Du Xia, Lei Xinyu, Wang Gang, Wang Zhengtao, Du Yiting, Bai Fangfang, Yuan Dajiang
Department of Cardiac Rehabilitation, Shanxi Cardiovascular Hospital, Taiyuan, Shanxi, China.
Department of Cardiology, Shanxi Cardiovascular Hospital, Taiyuan, Shanxi, China.
Front Cardiovasc Med. 2025 Jul 24;12:1560243. doi: 10.3389/fcvm.2025.1560243. eCollection 2025.
To investigate the efficacy of cardiac rehabilitation in patients with long COVID combined with coronary heart disease (CHD).
This retrospective study included 89 patients with long COVID, who were divided into CHD group and non-CHD group. The clinical indexes such as maximum heart rate and oxygen saturation during cardiac rehabilitation were compared between the two groups of subjects. The 6-minute walk test (6-MWT), Pittsburgh Sleep Quality Index (PSQI), 7-item Generalized Anxiety Disorder Scale (GAD-7), Nicotine Dependence Detection Scale (FTND) and the Depression Screening Scale (PHQ-9) were administered to patients. The same measures were re-administered to the patients after 3 months to explore the long-term effects of cardiac rehabilitation therapy.
Before receiving treatment, the maximum heart rate, maximum diastolic blood pressure and minimum SpO of the CHD group were significantly lower than those of the non-CHD group. The maximum heart rate, maximum systolic blood pressure, and 6-MWT were significantly lower before treatment than those at three months for both groups of patients. The PSQI, GAD-7, PHQ-9, and FTND scores were significantly higher before treatment than those at three months for both groups of patients. Comparison of differences between the two groups before and after treatment revealed that the CHD group had significantly worse cardiovascular measurements after SARS-CoV-2 infection than the non-CHD group.
Patients with long COVID combined with CHD have more severe symptoms, especially for their cardiac function. Cardiac rehabilitation can effectively improve patients' symptoms, and has long-term effects.
探讨心脏康复对新冠后综合征合并冠心病（CHD）患者的疗效。
这项回顾性研究纳入了89例新冠后综合征患者，将其分为冠心病组和非冠心病组。比较两组受试者在心脏康复期间的最大心率和血氧饱和度等临床指标。对患者进行6分钟步行试验（6-MWT）、匹兹堡睡眠质量指数（PSQI）、广泛性焦虑障碍7项量表（GAD-7）、尼古丁依赖检测量表（FTND）和抑郁筛查量表（PHQ-9）评估。3个月后对患者再次进行相同测量，以探讨心脏康复治疗的长期效果。
治疗前，冠心病组的最大心率、最大舒张压和最低SpO显著低于非冠心病组。两组患者治疗前的最大心率、最大收缩压和6-MWT均显著低于治疗3个月时。两组患者治疗前的PSQI、GAD-7、PHQ-9和FTND评分均显著高于治疗3个月时。治疗前后两组间差异比较显示，新冠病毒感染后冠心病组的心血管测量指标比非冠心病组显著更差。
新冠后综合征合并冠心病的患者症状更严重，尤其是心功能方面。心脏康复可有效改善患者症状，并具有长期效果。
