The Aga Khan University, Karachi, Pakistan.
Curr Atheroscler Rep. 2023 Sep;25(9):559-569. doi: 10.1007/s11883-023-01131-0. Epub 2023 Aug 2.
In this narrative review, we highlight different ways in which the COVID-19 pandemic has impacted coronary heart disease (CHD) burden and how a surge in morbidity and mortality may be expected in the near future. We also discuss potential solutions, and the direction subsequent research and corrective actions should take.
COVID-19 has been implicated in the development and worsening of CHD via acute and chronic mechanisms in the form of plaque rupture, destabilization, and sustenance of a chronic inflammatory state leading to long COVID syndrome and increased rates of myocardial infarction. However, indirectly the pandemic is likely to further escalate the CHD burden through poor health behaviors such as tobacco consumption, reduced physical activity, economic devastation and its associated sequelae, and regular cardiac care interruptions and delays. COVID-19 has increased the total CHD burden and will require extensive resource allocation and multifaceted strategies to curb future rise.
在这篇叙述性综述中，我们强调了 COVID-19 大流行如何影响冠心病（CHD）负担，以及在不久的将来如何预计发病率和死亡率会上升。我们还讨论了潜在的解决方案，以及后续研究和纠正措施的方向。
COVID-19 通过急性和慢性机制，如斑块破裂、不稳定和维持慢性炎症状态，导致长 COVID 综合征和心肌梗死发生率增加，被认为与 CHD 的发生和恶化有关。然而，大流行可能通过不良的健康行为，如烟草消费、体力活动减少、经济破坏及其相关后果，以及常规心脏护理中断和延迟，间接进一步加剧 CHD 负担。COVID-19 增加了 CHD 的总负担，需要广泛的资源配置和多方面的策略来遏制未来的上升。
