冻融卵裂期胚胎来源囊胚移植的生殖结局：一项系统评价与Meta分析
Reproductive Outcomes of Transferring Blastocysts Derived From Frozen-Thawed Cleavage Embryos: A Systematic Review and Meta-Analysis.
作者信息
Tran Huy Phuong, Nguyen Nam Nhat, Truong Ngoc Thanh, Hoang Tuyet Thi-Diem, Huynh Trang Nguyen-Khanh, Tran Ha Le-Bao
机构信息
Faculty of Biology and Biotechnology University of Science Ho Chi Minh City Vietnam.
Laboratory of Tissue Engineering and Biomedical Materials University of Science Ho Chi Minh City Vietnam.
出版信息
Reprod Med Biol. 2025 Aug 7;24(1):e12673. doi: 10.1002/rmb2.12673. eCollection 2025 Jan-Dec.
BACKGROUND
In in vitro fertilization (IVF), transferring frozen-thawed blastocysts is a widely adopted practice. This meta-analysis aims to evaluate the reproductive outcomes of transferring blastocysts derived from frozen-thawed cleavage embryos (FT-CDB group) compared to direct frozen-thawed blastocyst (DFB group) transfers.
METHODS
We searched the following electronic databases for relevant studies: PubMed/MEDLINE, EMBASE, Scopus, and Web of Science. Studies were included if they compared the clinical and neonatal outcomes of IVF patients receiving either FT-CDB or DFB transfer with vitrification method. The protocol for this review has been registered in PROSPERO.
RESULTS
A total of seven studies (2057 patients) were included in the analysis. Participants in the FT-CDB group demonstrated significantly higher odds of achieving clinical pregnancy (OR 1.24, 95% CI 1.03-1.49, = 0.022, = 27%), and live birth (OR 1.31, 95% CI 1.08-1.60, = 0.007, = 0%) compared to the DFB group. No significant differences were observed in the birth weights of infants between the groups (MD -87.05 g, 95% CI -293.77 to 119.67, = 0.41, = 83%).
CONCLUSION
Transferring blastocysts derived from frozen-thawed cleavage embryos is associated with higher odds of clinical pregnancy and live birth compared to frozen-thawed blastocyst transfers.
TRIAL REGISTRATION
PROSPERO number: CRD42024591620.
背景
在体外受精（IVF）中，移植冻融囊胚是一种广泛采用的做法。本荟萃分析旨在评估与直接移植冻融囊胚（DFB组）相比，移植冻融卵裂期胚胎来源的囊胚（FT-CDB组）的生殖结局。
方法
我们在以下电子数据库中检索相关研究：PubMed/MEDLINE、EMBASE、Scopus和Web of Science。纳入比较采用玻璃化方法进行FT-CDB或DFB移植的IVF患者临床和新生儿结局的研究。本综述方案已在PROSPERO注册。
结果
分析共纳入7项研究（2057例患者）。与DFB组相比，FT-CDB组患者临床妊娠（OR 1.24，95%CI 1.03-1.49，P = 0.022，I² = 27%）和活产（OR 1.31，95%CI 1.08-1.60，P = 0.007，I² = 0%）的几率显著更高。两组间婴儿出生体重无显著差异（MD -87.05g，95%CI -293.77至119.67，P = 0.41，I² = 83%）。
结论
与移植冻融囊胚相比，移植冻融卵裂期胚胎来源的囊胚临床妊娠和活产几率更高。
试验注册
PROSPERO编号：CRD42024591620。
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