Liu Jinbo, Cui Xuechen, Jiang Shantong, Wang Jin, Wen Huan, Xiong Kun, Zhao Hongwei, Zhao Na, Wang Hongyu
Department of Vascular Medicine, Peking University Shougang Hospital, Jinyuanzhuang Road 9, Shijingshan District, Beijing 100144, PR China.
Beijing Shijingshan District Key Clinical Specialty of Vascular Medicine, Beijing 100144, PR China.
Int J Cardiol Heart Vasc. 2025 Jul 28;60:101761. doi: 10.1016/j.ijcha.2025.101761. eCollection 2025 Oct.
Ankle-brachial index (ABI) is used to diagnose peripheral artery disease. Arterial stiffness could be measured by carotid-femoral pulse wave velocity (CF-PWV). The study was to investigate relationship between ABI and CF-PWV in patients with hypertension and diabetes mellitus.
1577 patients (M/F 812/765) from Department of Vascular Medicine were enrolled. ABI was recorded by VaseraVS-1000 vascular screening system (Fukuda Denshi, Tokyo, Japan). CF-PWV was recorded by Complior apparatus.
CF-PWV was significantly higher in hypertension patients with diabetes mellitus than hypertension patients without diabetes mellitus (13.77 ± 3.91 vs 11.83 ± 3.26 m/s, p < 0.05). Right ABI was significantly lower in hypertension patients with diabetes mellitus than hypertension patients without diabetes mellitus (1.062 ± 0.163 vs 1.102 ± 0.105, p < 0.05). Right ABI was negatively correlated with age, systolic blood pressure, CF-PWV and creatinine in entire study group (r = -0.081, p = 0.001; r = -0.069,p < 0.001; r = -0.178, p < 0.001; r = -0.124, p < 0.001, respectively). Multiple linear regressions found that CF-PWV, body mass index (BMI), gender, creatinine, total cholesterol, uric acid and diabetes mellitus were independent associating factors of RABI in all patients (β = -0.168, p < 0.001; β = 0.180, p < 0.001; β = -0.189, p < 0.001; β = -0.102, p = 0.008; β = 0.088, p = 0.004; β = -0.100, p = 0.009;β = -0.062, p = 0.043; respectively). CF-PWV, BMI, gender and HDL-C were independent associating factors of left ABI in all patients (β = -0.170, p < 0.001; β = 0.172, p < 0.001; β = -0.104, p = 0.001; β = 0.074, p = 0.023; respectively).
ABI was significantly lower in hypertension patients with diabetes mellitus, with higher level of CF-PWV. CF-PWV was an independent associating factor of ABI, indicating the greater the elasticity of the large arteries, the higher the probability of lower limb artery occlusion.
踝臂指数（ABI）用于诊断外周动脉疾病。动脉僵硬度可通过颈股脉搏波速度（CF-PWV）来测量。本研究旨在探讨高血压合并糖尿病患者的ABI与CF-PWV之间的关系。
纳入血管医学科的1577例患者（男812例，女765例）。使用VaseraVS-1000血管筛查系统（日本东京福田电子）记录ABI。使用Complior设备记录CF-PWV。
高血压合并糖尿病患者的CF-PWV显著高于无糖尿病的高血压患者（13.77±3.91 vs 11.83±3.26 m/s，p<0.05）。高血压合并糖尿病患者的右侧ABI显著低于无糖尿病的高血压患者（1.062±0.163 vs 1.102±0.105，p<0.05）。在整个研究组中，右侧ABI与年龄、收缩压、CF-PWV和肌酐呈负相关（r=-0.081，p=0.001；r=-0.069，p<0.001；r=-0.178，p<0.001；r=-0.124，p<0.001）。多元线性回归发现，CF-PWV、体重指数（BMI）、性别、肌酐、总胆固醇、尿酸和糖尿病是所有患者右侧ABI的独立相关因素（β=-0.168，p<0.001；β=0.180，p<0.001；β=-0.189，p<0.001；β=-0.102，p=0.008；β=0.088，p=0.004；β=-0.100，p=0.009；β=-0.062，p=0.043）。CF-PWV、BMI、性别和高密度脂蛋白胆固醇（HDL-C）是所有患者左侧ABI的独立相关因素（β=-0.170，p<0.001；β=0.172，p<0.001；β=-0.104，p=0.001；β=0.074，p=0.023）。
高血压合并糖尿病患者的ABI显著降低，CF-PWV水平较高。CF-PWV是ABI的独立相关因素，表明大动脉弹性越差，下肢动脉闭塞的可能性越高。
