Chen Jianbai, Mou Xiaorong, Zhang Zhiming, Nie Zhiyong, Qiu Jianxin
Air Force Medical University, Xi'an, China.
Department of Pathology, Tangdu Hospital, Xi'an, China.
Front Urol. 2025 Feb 6;5:1440538. doi: 10.3389/fruro.2025.1440538. eCollection 2025.
Primary neuroendocrine carcinoma of the urethra is a very uncommon malignant tumor, and no reports have been made about large cell neuroendocrine carcinoma (LCNEC) in the past.
A 43-year-old non-smoking female patient presented with symptoms of dysuria and urination-related pain at TangDu Hospital in April 2022. A biopsy subsequently confirmed the diagnosis of primary urethral LCNEC. Following radical resection, the patient exhibited abnormal lymph node enlargement in the first month and pelvic metastases in the fourth month. Ultimately, the patient succumbed to the disease 486 days after the radical resection, attributed to widespread tumor metastases and concurrent multi-organ failure. The final pathological examination confirmed the presence of a high-grade LCNEC.
The occurrence of primary LCNEC in the urethra is exceptionally uncommon. This particular instance was notable for its aggressive progression and unfavorable prognosis. Historically, there have been no prior documented instances of primary pure LCNEC in the urethra. It is imperative to emphasize that early identification and intervention for LCNEC could potentially offer patients a more favorable survival outcome.
原发性尿道神经内分泌癌是一种非常罕见的恶性肿瘤，过去尚无关于大细胞神经内分泌癌（LCNEC）的报道。
一名43岁不吸烟女性患者于2022年4月在唐都医院出现排尿困难和排尿相关疼痛症状。随后活检确诊为原发性尿道LCNEC。根治性切除术后，患者在第一个月出现异常淋巴结肿大，第四个月出现盆腔转移。最终，患者在根治性切除术后486天因广泛肿瘤转移和并发多器官衰竭而死亡。最终病理检查证实为高级别LCNEC。
原发性尿道LCNEC的发生极为罕见。这个特殊病例以其侵袭性进展和不良预后而引人注目。历史上，尿道原发性纯LCNEC尚无先前记录的病例。必须强调的是，对LCNEC进行早期识别和干预可能会为患者提供更有利的生存结果。
