Martín Iván J Povo, Vilar Daniel Gallego, Aguado Jaume Miralles, Perelló Carmen Garau, Aliaga Miguel Rodrigo, Argente Vicente Gimeno, Ferreres Luis Alfaro, Gómez Juan Gallego
Urology Department, Hospital General de Castellón, Spain.
Arch Esp Urol. 2011 Mar;64(2):105-13.
Large cell neuroendocrine carcinoma (LCNEC) of the urinary bladder is very rare. We intend to update diagnostic criteria, pathologic and immunohistochemical characteristics, prognosis and treatment options. All published articles related with LCNEC of the urinary bladder have been reviewed and a descriptive study has been done.
A total of 17 LCNEC of the bladder has been found. The 50% of all LCNEC of the bladder are mixed histological variant. This variant implies a better prognosis than the pure variant. The 70% of LCNEC of the bladder were ≥T3 at the time of diagnosis and the survival rate was 25%, whereas T2 tumors showed a survival rate of 100%. Radical cystectomy with lymphadenectomy combined with chemotherapy can sometimes reduce local and distant recurrence and improve survival of LCNEC of the bladder.
LCNEC of the bladder is a tumor with high rate of local and distant recurrence, as well as low survival, requiring early diagnosis and aggressive combined treatment.
膀胱大细胞神经内分泌癌（LCNEC）非常罕见。我们旨在更新其诊断标准、病理及免疫组化特征、预后和治疗选择。我们回顾了所有已发表的与膀胱LCNEC相关的文章，并进行了一项描述性研究。
共发现17例膀胱LCNEC。所有膀胱LCNEC中有50%为混合组织学变异型。该变异型的预后比纯变异型更好。70%的膀胱LCNEC在诊断时为≥T3期，生存率为25%，而T2期肿瘤的生存率为100%。根治性膀胱切除术加淋巴结清扫术联合化疗有时可降低膀胱LCNEC的局部和远处复发率，并提高生存率。
膀胱LCNEC是一种局部和远处复发率高、生存率低的肿瘤，需要早期诊断和积极的综合治疗。
