Bind M-A C, Rubin D B
Biostatistics Center, Massachusetts General Hospital, Boston, MA, USA.
Department of Medicine, Harvard Medical School, Boston, MA, USA.
Am Stat. 2025;79(2):275-285. doi: 10.1080/00031305.2024.2432884. Epub 2025 Jan 17.
Consider a study whose primary results are "not statistically significant". How often does it lead to the following published conclusion that "there is no effect of the treatment/exposure on the outcome"? We believe too often and that the requirement to report counternull values could help to avoid this! In statistical parlance, the null value of an estimand is a value that is distinguished in some way from other possible values, for example a value that indicates no difference between the general health status of those treated with a new drug versus a traditional drug. A counternull value is a nonnull value of that estimand that is supported by the same amount of evidence that supports the null value. Of course, such a definition depends critically on how "evidence" is defined. Here, we consider the context of a randomized experiment where evidence is summarized by the randomization-based p-value associated with a specified sharp null hypothesis. Consequently, a counternull value has the same p-value from the randomization test as does the null value; the counternull value is rarely unique, but rather comprises a of values. We explore advantages to reporting a counternull set in addition to the p-value associated with a null value; a first advantage is pedagogical, in that reporting it avoids the mistake of implicitly accepting a not-rejected null hypothesis; a second advantage is that the effort to construct a counternull set can be scientifically helpful by encouraging thought about nonnull values of estimands. Two examples are used to illustrate these ideas.
考虑一项主要结果“无统计学显著性”的研究。它得出以下已发表结论“治疗/暴露对结局无影响”的频率有多高?我们认为这种情况太常见了,而报告反虚无值的要求有助于避免这种情况!在统计学用语中,估计量的虚无值是在某些方面与其他可能值有所区别的值,例如,该值表明用新药治疗的人群与用传统药物治疗的人群的总体健康状况无差异。反虚无值是该估计量的一个非虚无值,它得到的证据量与支持虚无值的证据量相同。当然,这样的定义严重依赖于“证据”是如何定义的。在此,我们考虑随机试验的背景,其中证据由与特定精确虚无假设相关的基于随机化的p值汇总。因此,反虚无值与虚无值在随机化检验中的p值相同;反虚无值很少是唯一的,而是由一组值组成。我们探讨了除报告与虚无值相关的p值之外,报告反虚无值集的优势;第一个优势具有教学意义,即报告它可避免隐含地接受未被拒绝的虚无假设的错误;第二个优势是,构建反虚无值集的努力通过鼓励对估计量的非虚无值进行思考,在科学上可能会有所帮助。我们用两个例子来说明这些观点。