Ran Linbin, Pan Wei, Feng Jianguo, Tang Liling
Key Laboratory of Biorheological Science and Technology, Ministry of Education, College of Bioengineering, Chongqing University, Chongqing 400044, China.
Laboratory for Integrated Chinese and Western Medicine in the Prevention and Treatment of Organ Fibrosis, Department of Nephrology, The Affiliated Traditional Chinese Medicine Hospital, Southwest Medical University, Luzhou, Sichuan 646000, China.
Mol Ther Nucleic Acids. 2025 Jul 17;36(3):102630. doi: 10.1016/j.omtn.2025.102630. eCollection 2025 Sep 9.
Long non-coding RNAs (lncRNAs) play critical roles in development and pathogenesis of various diseases. Notably, lncRNA-metastasis-associated lung adenocarcinoma transcript 1() is among the most essential lncRNAs affecting various processes, including cell proliferation and apoptosis. Moreover, complex interactions between and fibrosis have attracted research interest to understand the pathophysiology of fibrotic diseases. This literature review discusses the existing research on the correlations between and various fibrotic diseases, including hepatic, pulmonary, renal, and myocardial fibrosis, focusing on the underlying molecular mechanisms. Additionally, this review lists the currently available -targeted agents, such as nucleic acid drugs and small-molecule inhibitors, highlighting potential targets and strategies for fibrotic diseases treatment.
长链非编码RNA（lncRNAs）在各种疾病的发生发展及发病机制中发挥着关键作用。值得注意的是，lncRNA-转移相关肺腺癌转录本1（）是影响包括细胞增殖和凋亡在内的各种过程的最重要的lncRNAs之一。此外，与纤维化之间的复杂相互作用已引起研究兴趣，以了解纤维化疾病的病理生理学。这篇文献综述讨论了关于与各种纤维化疾病（包括肝纤维化、肺纤维化、肾纤维化和心肌纤维化）之间相关性的现有研究，重点关注潜在的分子机制。此外，本综述列出了目前可用的靶向药物，如核酸药物和小分子抑制剂，强调了纤维化疾病治疗的潜在靶点和策略。
