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长链非编码RNA：纤维化疾病中的关键因素。

Long non-coding RNA : A crucial factor in fibrotic diseases.

作者信息

Ran Linbin, Pan Wei, Feng Jianguo, Tang Liling

机构信息

Key Laboratory of Biorheological Science and Technology, Ministry of Education, College of Bioengineering, Chongqing University, Chongqing 400044, China.

Laboratory for Integrated Chinese and Western Medicine in the Prevention and Treatment of Organ Fibrosis, Department of Nephrology, The Affiliated Traditional Chinese Medicine Hospital, Southwest Medical University, Luzhou, Sichuan 646000, China.

出版信息

Mol Ther Nucleic Acids. 2025 Jul 17;36(3):102630. doi: 10.1016/j.omtn.2025.102630. eCollection 2025 Sep 9.

DOI:10.1016/j.omtn.2025.102630
PMID:40777744
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12329540/
Abstract

Long non-coding RNAs (lncRNAs) play critical roles in development and pathogenesis of various diseases. Notably, lncRNA-metastasis-associated lung adenocarcinoma transcript 1() is among the most essential lncRNAs affecting various processes, including cell proliferation and apoptosis. Moreover, complex interactions between and fibrosis have attracted research interest to understand the pathophysiology of fibrotic diseases. This literature review discusses the existing research on the correlations between and various fibrotic diseases, including hepatic, pulmonary, renal, and myocardial fibrosis, focusing on the underlying molecular mechanisms. Additionally, this review lists the currently available -targeted agents, such as nucleic acid drugs and small-molecule inhibitors, highlighting potential targets and strategies for fibrotic diseases treatment.

摘要

长链非编码RNA（lncRNAs）在各种疾病的发生发展及发病机制中发挥着关键作用。值得注意的是，lncRNA-转移相关肺腺癌转录本1（）是影响包括细胞增殖和凋亡在内的各种过程的最重要的lncRNAs之一。此外，与纤维化之间的复杂相互作用已引起研究兴趣，以了解纤维化疾病的病理生理学。这篇文献综述讨论了关于与各种纤维化疾病（包括肝纤维化、肺纤维化、肾纤维化和心肌纤维化）之间相关性的现有研究，重点关注潜在的分子机制。此外，本综述列出了目前可用的靶向药物，如核酸药物和小分子抑制剂，强调了纤维化疾病治疗的潜在靶点和策略。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0240/12329540/a5391bcd0ad8/gr3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0240/12329540/74e75859962b/fx1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0240/12329540/df0bb5535eaa/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0240/12329540/4ee3f8df4a6c/gr2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0240/12329540/a5391bcd0ad8/gr3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0240/12329540/74e75859962b/fx1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0240/12329540/df0bb5535eaa/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0240/12329540/4ee3f8df4a6c/gr2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0240/12329540/a5391bcd0ad8/gr3.jpg

相似文献

[1]
Long non-coding RNA : A crucial factor in fibrotic diseases.

Mol Ther Nucleic Acids. 2025-7-17

[2]
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[9]
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[10]
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本文引用的文献

[1]
5-methylcytosine methylation of MALAT1 promotes resistance to sorafenib in hepatocellular carcinoma through ELAVL1/SLC7A11-mediated ferroptosis.

Drug Resist Updat. 2025-1

[2]
Visualization and Quantification of Single-Base mA Methylation.

Angew Chem Int Ed Engl. 2025-2-3

[3]
Ginsenoside Rg1 Regulates the Activation of Astrocytes Through lncRNA-Malat1/miR-124-3p/Lamc1 Axis Driving PI3K/AKT Signaling Pathway, Promoting the Repair of Spinal Cord Injury.

CNS Neurosci Ther. 2024-11

[4]
Paeoniae radix alba improved intestinal mucosal microcirculation disturbance by regulating lncRNA MALAT1/HIF-1α pathway in the treatment of ulcerative colitis.

Phytomedicine. 2024-12

[5]
Antisense Oligonucleotide Embedded Context Responsive Nanoparticles Derived from Synthetic Ionizable Lipids for lncRNA Targeted Therapy of Breast Cancer.

ACS Appl Mater Interfaces. 2024-9-4

[6]
LncRNA MALAT1 Knockdown Alleviates Fibrogenic Response in Human Endometrial Stromal Cells Via the miR-22-3p/TGFβR1/Smad2/3 Pathway.

Cell Biochem Biophys. 2024-12

[7]
Targeting the transferrin receptor to transport antisense oligonucleotides across the mammalian blood-brain barrier.

Sci Transl Med. 2024-8-14

[8]
CRISPR-Enhanced Photocurrent Polarity Switching for Dual-lncRNA Detection Combining Deep Learning for Cancer Diagnosis.

Anal Chem. 2024-8-13

[9]
Structural basis of MALAT1 RNA maturation and mascRNA biogenesis.

Nat Struct Mol Biol. 2024-11

[10]
Development of a DNAzyme-Driven Fluorescent Light-Up Aptasensor for Label-Free Detection of Multiple lncRNAs.

Anal Chem. 2024-7-16

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