Xu Zejun, Chi Jiaying, Qin Fei, Liu Dongyan, Lai Yecai, Bao Yingxia, Guo Ruizhi, Liao Yiqiu, Xie Zhoufan, Jiang Jieqiong, Liu Juyan, Cai Jianfeng, Lu Chao, Wang Jiansong, Wu Chuanbin
State Key Laboratory of Bioactive Molecules and Druggability Assessment, Guangdong Basic Research Center of Excellence for Natural Bioactive Molecules and Discovery of Innovative Drugs, College of Pharmacy, Jinan University, Guangzhou 511436, China.
Baiyunshan Pharmaceutical General Factory, Guangzhou Baiyunshan Pharmaceutical Holdings Co., Ltd., Guangzhou 510515, China.
Asian J Pharm Sci. 2025 Aug;20(4):101069. doi: 10.1016/j.ajps.2025.101069. Epub 2025 May 24.
Nanoparticles-incorporated hydrogel microneedles (NPs-HMN) have attracted significant attention due to their exceptional biomedical applications. The arrayed needle tips of NPs-HMN effectively penetrate the skin or tissue, enabling minimally invasive and painless delivery of therapeutic molecules into the tissue microenvironment. This approach has shown significant improvements in bioavailability and patient compliance. Moreover, the functionalized hydrogel materials of NPs-HMN exhibit a three-dimensional network structure resembling the extracellular matrix, along with controllable drug release, exceptional swelling ability, hydrophilicity, and biocompatibility. These characteristics broaden the potential applications of HMN in therapeutic and biosensing contexts. In addition, the incorporation of nanoparticles (NPs) has been shown to improve the solubility of hydrophobic drugs, enhance mechanical properties, enable intelligent drug release, and facilitate precise targeting of HMN. The versatility and diversity of treatment options afforded by NPs-HMN contribute to significant advancements in animal models and clinical settings, as well as offer valuable insights for biomaterial development. This review provides a comprehensive examination of the fabrication strategies of NPs-HMN and their recent advancements in biomedical applications. We also analyze the mechanisms, advantages, challenges, and future prospects of this system in enhancing drug delivery efficiency to provide theoretical references for further breakthroughs in novel delivery platforms.
纳米颗粒复合水凝胶微针（NPs-HMN）因其卓越的生物医学应用而备受关注。NPs-HMN的阵列式针尖能够有效穿透皮肤或组织，实现治疗分子向组织微环境的微创无痛递送。这种方法在生物利用度和患者依从性方面有显著提高。此外，NPs-HMN的功能化水凝胶材料呈现出类似细胞外基质的三维网络结构，具有可控的药物释放、出色的溶胀能力、亲水性和生物相容性。这些特性拓宽了HMN在治疗和生物传感领域的潜在应用。此外，已证明纳米颗粒（NPs）的加入可提高疏水性药物的溶解度、增强机械性能、实现智能药物释放并促进HMN的精准靶向。NPs-HMN提供的治疗选择的多功能性和多样性推动了动物模型和临床环境中的重大进展，也为生物材料开发提供了有价值的见解。本文综述全面考察了NPs-HMN的制备策略及其在生物医学应用中的最新进展。我们还分析了该系统在提高药物递送效率方面的机制、优势、挑战和未来前景，为新型递送平台的进一步突破提供理论参考。
