Association of the Serpine1 with the Obesity Paradox in Ischemic Heart Failure.

BACKGROUND

Extreme obesity pathology is with a risk factor for heart failure (HF), whereas the obesity paradox in HF shows that obese subjects had a good prognosis. The mechanism underlying the obesity paradox in HF prognosis is unclear till now. We aimed to provide evidence for the molecular mechanisms of the obesity paradox in HF.

METHODS

Differentially expressed genes (DEGs) in ischemic HF samples were identified in the GSE57338 and GSE5406 datasets. Weighted gene co-expression network analysis (WGCNA) modules and a protein-protein interaction network (PPI) were constructed. HF-associated DEGs and pathways were screened in the Comparative Toxicogenomics Database (CTD). The expression of hub genes in adipose tissues from obese patients and LV samples from HF patients were validated in microarray datasets.

RESULTS

Three HF-associated WGCNA modules were identified and DEGs were associated with the 'hsa04115: signaling pathway'. was the only common gene between DEGs and HF-associated genes in the CTD database. The gene was downregulated in the white adipose tissues compared with brown adipose tissues ( = 3.90e-03) and was upregulated in the omental adipose tissues from obese patients compared with lean subjects ( = 3.85e-02).

CONCLUSION

The downregulation of expression might be responsible for the obesity paradox in HF via interacting with .