Hariri Zahra, Yari Zahra, Nilghaz Maryam, Mirhoseini Monirsadat, Hosseini Sedighe, Abhari Khadijeh, Sohrab Golbon
Department of Clinical Nutrition and Dietetics, Faculty of Nutrition Sciences and Food Technology, National Nutrition and Food Technology Research Institute, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Department of Nutrition Research, National Nutrition and Food Technology Research Institute, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Iran J Public Health. 2025 Jul;54(7):1540-1550. doi: 10.18502/ijph.v54i7.19160.
We aimed to investigate the effect of synbiotic supplement-containing spore-forming Bacillus coagulans (GBI-30) on the glycemic, hormonal and anthropometric parameters in patients with PCOS.
In this randomized, triple-blind, placebo-controlled trial, 72 patients with PCOS were randomly and equally assigned to receive a daily sachet of synbiotic (containing Bacillus coagulans (GBI-30), Lactobacillus rhamnosus, Lactobacillus helveticus, and fructooligosaccharide (FOS)) or placebo for 12 wk. Glycemic, hormonal and anthropometric parameters were measured at baseline and after the 12-week of intervention.
At the end, 60 patients completed the study. After adjustment for potential confounders, significant decrease in insulin (-3.38±20.20 vs. +2.33, =0.042), homeostatic model assessment for insulin resistance (HOMA-IR) (-0.43±3.61 vs. +0.73 ± 2.91, =0.044) and dehydroepiandrosterone sulfate (DHEAS) (-1.47±6.62 vs. + 0.03 ± 2.06, =0.047) was observed in the intervention group compared to the control group. Supplementation with synbiotic failed to show a significant effect on anthropometric parameters and fasting blood sugar.
Overall, 12 wk supplementation with synbiotic-containing Bacillus coagulans (GBI-30) can offer additional benefit to lifestyle intervention on metabolic status of women with polycystic ovarian syndrome.
我们旨在研究含芽孢杆菌凝结芽孢杆菌（GBI-30）的合生元补充剂对多囊卵巢综合征（PCOS）患者血糖、激素和人体测量参数的影响。
在这项随机、三盲、安慰剂对照试验中，72例PCOS患者被随机且平均分为两组，分别每日接受一袋合生元（含凝结芽孢杆菌（GBI-30）、鼠李糖乳杆菌、瑞士乳杆菌和低聚果糖（FOS））或安慰剂，为期12周。在基线和干预12周后测量血糖、激素和人体测量参数。
最后，60例患者完成了研究。在调整潜在混杂因素后，与对照组相比，干预组的胰岛素（-3.38±20.20对+2.33，P=0.042）、胰岛素抵抗稳态模型评估（HOMA-IR）（-0.43±3.61对+0.73±2.91，P=0.044）和硫酸脱氢表雄酮（DHEAS）（-1.47±6.62对+0.03±2.06，P=0.047）显著降低。补充合生元对人体测量参数和空腹血糖未显示出显著影响。
总体而言，含凝结芽孢杆菌（GBI-30）的合生元补充12周可为多囊卵巢综合征女性的生活方式干预代谢状况带来额外益处。
