益生菌和合生元补充剂对多囊卵巢综合征女性胰岛素抵抗的影响：一项荟萃分析。
Effects of probiotic and synbiotic supplementation on insulin resistance in women with polycystic ovary syndrome: a meta-analysis.
作者信息
Miao Chenyun, Guo Qingge, Fang Xiaojie, Chen Yun, Zhao Ying, Zhang Qin
机构信息
Department of TCM Gynaecology, Hangzhou TCM Hospital Affiliated to Zhejiang Chinese Medical University, Hangzhou, Zhejiang Province, China.
Department of TCM, Hangzhou Women's Hospital, Hangzhou, Zhejiang Province, China.
出版信息
J Int Med Res. 2021 Jul;49(7):3000605211031758. doi: 10.1177/03000605211031758.
OBJECTIVE
This meta-analysis evaluated the effect of probiotics and synbiotics on insulin resistance in patients with polycystic ovary syndrome (PCOS).
METHODS
A systematic search was performed to identify all relevant publications listed on the electronic databases (PubMed®, Web of Science, Embase® and China National Knowledge Infrastructure) between inception and 30 October 2020. All statistical analyses were performed on randomized controlled trials (RCTs) using RevMan version 5.3 software provided by the Cochrane Collaboration.
RESULTS
A total of 486 patients from seven RCTs were included in the meta-analysis. Probiotic and synbiotic supplementation appeared to improve levels of homeostatic model assessment of insulin resistance (mean difference = -0.37; 95% confidence interval -0.69, -0.05) and serum insulin (standardized mean difference = -0.66; 95% confidence interval -1.19, -0.12). The results failed to show any influence of probiotic and synbiotic supplementation on body mass index, waist circumference, hip circumference and fasting blood sugar.
CONCLUSIONS
Probiotics and synbiotics appear to have a partially beneficial effect on indices of insulin resistance in patients with PCOS.
目的
本荟萃分析评估了益生菌和合生元对多囊卵巢综合征（PCOS）患者胰岛素抵抗的影响。
方法
进行系统检索，以识别在2020年10月30日之前电子数据库（PubMed®、Web of Science、Embase®和中国知网）中列出的所有相关出版物。所有统计分析均使用Cochrane协作网提供的RevMan 5.3版软件对随机对照试验（RCT）进行。
结果
本荟萃分析共纳入了来自7项RCT的486例患者。补充益生菌和合生元似乎能改善胰岛素抵抗的稳态模型评估水平（平均差=-0.37；95%置信区间-0.69，-0.05）和血清胰岛素水平（标准化平均差=-0.66；95%置信区间-1.19，-0.12）。结果未显示补充益生菌和合生元对体重指数、腰围、臀围和空腹血糖有任何影响。
结论
益生菌和合生元似乎对PCOS患者的胰岛素抵抗指标有部分有益作用。
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