Jamir Imola, Joseph Noyal Mariya, Kannambath Rachana, Kumar Pradeep
JIPMER, Microbiology.
Afr Health Sci. 2024 Sep;24(3):69-74. doi: 10.4314/ahs.v24i3.10.
Mycobacterium (M.) bovis is a member of Mycobacterium tuberculosis complex (MTBC). Clinical infection caused by is indistinguishable from other MTBC and could pose a potential challenge for control of TB epidemic due to its zoonotic nature. Availability of reliable molecular diagnostic methods such as Genotype MTBC based on line probe assay (LPA) paves way for reliable differentiation of M. bovis from other MTBC.
To determine the proportion of Mycobacterium bovis among the Mycobacterium tuberculosis complex isolates from patients with tuberculosis.
In our study, we analysed MGIT positive cultures and performed Line probe assay (LPA) for identification of MTBC isolates. Total of 206 patient samples were taken, 104 pulmonary and 102 from extrapulmonary sites.
was isolated in all pulmonary specimens (100%). Among 102 extrapulmonary samples, 99 % was identified as M.tuberculosis/M.canettii, and 1 % as M. bovis BCG.
Our study suggests that zoonotic TB by may not be as prevalent in India and hence may not constitute a significant risk to public health in India.
牛分枝杆菌是结核分枝杆菌复合群（MTBC）的成员之一。由其引起的临床感染与其他MTBC感染难以区分，并且由于其人畜共患的特性，可能对结核病流行的控制构成潜在挑战。基于线性探针分析（LPA）的可靠分子诊断方法，如Genotype MTBC，为牛分枝杆菌与其他MTBC的可靠区分铺平了道路。
确定结核病患者结核分枝杆菌复合群分离株中牛分枝杆菌的比例。
在我们的研究中，我们分析了MGIT阳性培养物，并进行线性探针分析（LPA）以鉴定MTBC分离株。共采集了206份患者样本，其中104份来自肺部，102份来自肺外部位。
在所有肺部标本中均分离出（100%）。在102份肺外样本中，99%被鉴定为结核分枝杆菌/卡内蒂分枝杆菌，1%为卡介苗牛分枝杆菌。
我们的研究表明，牛分枝杆菌引起的人畜共患结核病在印度可能不那么普遍，因此可能不会对印度的公共卫生构成重大风险。
Zotero 插件