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印度昌迪加尔地区全国结核病防治规划下复治肺结核患者的治疗结果

Treatment Outcome Among the Retreatment Tuberculosis (TB) Patients under RNTCP in Chandigarh, India.

作者信息

Sarpal Sandeep Singh, Goel Naveen Krishan, Kumar Dinesh, Janmeja A K

机构信息

Demonstrator, Department of Community Medicine, Government Medical College and Hospital , Sector-32, Chandigarh, India .

Professor and Head, Department of Community Medicine, Government Medical College and Hospital , Sector-32, Chandigarh, India .

出版信息

J Clin Diagn Res. 2014 Feb;8(2):53-6. doi: 10.7860/JCDR/2014/6510.4006. Epub 2014 Feb 3.

Abstract

BACKGROUND

'RETREATMENT' for Tuberculosis (TB) has long been a neglected area in global TB control. While other components of the Stop TB Strategy have garnered appropriate focus and, increasingly, sufficient resources, issues related to the TB of patients previously treated for tuberculosis remain under examined and under-resourced.

METHODS

A longitudinal study was designed and the patients registered under Revised National Tuberculosis Control Programme (RNTCP) category II from June 2010 to December 2011.Out of total 607 patients registered during this period under category II of RNTCP in Chandigarh (India), 545 consented to participate in the study. These were followed up to September 2012 till the completion of treatment.

STATISTICAL ANALYSIS

The analysis was done by using SPPS-18 statistical software package. Chi- square test was used for testing association of different characteristics.

RESULTS

Four Hundred Thirty (78.9%) of the patients had pulmonary TB and 115(21.1%) of the patients had extra pulmonary TB. In the study cohort of category II patients 264(48.4%) were relapse patients,167(30.6%) belonged to others category, 75(13.8%) were on treatment after default, 39(7.2%) were failure cases. The mean age of patients was 35.92 ± 15.42 (p = 0.928). Maximum patients belonged to age group of 25-34 years (25.3%). Seventy Three (13.4%) were Illiterate. In treatment after default group only 65.3% patients were cured. Maximum deaths 8% were seen in treatment after default group of patients. The overall default in the study was 5.9%.

CONCLUSION

The findings of this study suggest that it is essential to monitor re-treatment patients with same vigour to reduce default and improve their treatment outcome.

摘要

背景

结核病“复治”长期以来一直是全球结核病控制中被忽视的领域。虽然“终止结核病战略”的其他组成部分已得到适当关注,并且越来越多地获得了充足资源,但与先前接受过结核病治疗的患者的结核病相关问题仍未得到充分研究,资源也不足。

方法

设计了一项纵向研究,对2010年6月至2011年12月期间在修订后的国家结核病控制规划(RNTCP)第二类登记的患者进行研究。在印度昌迪加尔在此期间RNTCP第二类登记的607名患者中,545名同意参与研究。对这些患者进行随访至2012年9月直至治疗结束。

统计分析

使用SPPS - 18统计软件包进行分析。卡方检验用于检验不同特征之间的关联。

结果

430名(78.9%)患者患有肺结核,115名(21.1%)患者患有肺外结核。在第二类患者的研究队列中,264名(48.4%)为复发患者,167名(30.6%)属于其他类别,75名(13.8%)为中断治疗后重新治疗的患者,39名(7.2%)为治疗失败病例。患者的平均年龄为35.92±15.42(p = 0.928)。最大比例的患者属于25 - 34岁年龄组(25.3%)。73名(13.4%)为文盲。在中断治疗后重新治疗组中,仅65.3%的患者治愈。中断治疗后重新治疗组的患者中出现的最大死亡率为8%。该研究中的总体中断率为5.9%。

结论

本研究结果表明,必须以同样的力度监测复治患者,以减少治疗中断并改善其治疗结果。

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