TP53基因的Arg72Pro多态性和MDM2基因的T309G多态性与膀胱癌风险相关吗？一项荟萃分析。

Are TP53 Arg72Pro and MDM2 T309G polymorphisms associated with bladder cancer risk? A meta-analysis.

作者信息

Abderrahmane Rym-Khadidja, Touala-Chaila Zohra, Benseddik Khedidja, Hassani Nihed, Drider Hind, Derbouz-Draoua Imene, Meroufel Djebaria Naima

机构信息

Université des Sciences et de la Technologie d'Oran Mohamed-Boudiaf USTOMB El Mnaouar, BP 1505, Bir El Djir 31000, Oran, Algérie.

Laboratoire de la Génétique Moléculaire et Cellulaire (LGMC) USTOMB El Mnaouar, BP 1505, Bir El Djir 31000, Oran, Algérie.

出版信息

Afr Health Sci. 2024 Sep;24(3):118-127. doi: 10.4314/ahs.v24i3.16.

DOI:10.4314/ahs.v24i3.16

PMID:40777979

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12327109/

Abstract

BACKGROUND

We still do not know the exact cause of bladder cancer (BC).

OBJECTIVES

Evaluation of the effect of TP53 Arg72Pro and MDM2 T309G polymorphisms with the risk of Bladder cancer.

METHODS

A literature search was conducted followed by a meta-analysis. Then, sensitivity and subgroup analyses were performed. 14 relevant studies were included in the quantitative analysis.

RESULTS

No statistically significant associations were found. The results of the subgroup analysis revealed a significant association in the Turkish population for T309G: G vs. T (P-value= 0.015; OR 95%CI= 1.51 [1.084; 2.125]), GG vs.TT (P-value= 0.009; OR 95% CI= 2.60 [1.262; 5.370]). Sensitivity analysis revealed a significant association between the Arg72Pro: C vs. G (OR= 1.22, 95% CI [1.05; 1.40]), CC vs. GG (OR= 1.54; 95% CI [1.13; 2.09]), CC+CG vs. GG (OR= 1.24; 95% CI [1.01; 1.53]), CC vs. CG+GG (OR= 1.33; 95% CI [1.01; 1.74]), and T309G: G vs. T (OR= 1.30; 95% CI [1.07; 1.57]), GG vs. GT+TT (OR= 1.53; 95% CI [1.10; 2.11]), GG vs. GT (OR=1.44; 95% CI [1.02; 2.02]), GG vs. TT (OR= 1.88; 95% CI [1.25; 2.82]) with BC occurrence.

CONCLUSION

The T309G polymorphism was found to be a predisposing allele for BC in Turkish population.

摘要

背景

我们仍不清楚膀胱癌（BC）的确切病因。

目的

评估TP53基因Arg72Pro多态性和MDM2基因T309G多态性与膀胱癌风险的关系。

方法

进行文献检索并随后进行荟萃分析。然后，进行敏感性分析和亚组分析。定量分析纳入了14项相关研究。

结果

未发现具有统计学意义的关联。亚组分析结果显示，在土耳其人群中，T309G多态性存在显著关联：G与T相比（P值 = 0.015；OR 95%CI = 1.51 [1.084；2.125]），GG与TT相比（P值 = 0.009；OR 95%CI = 2.60 [1.262；5.370]）。敏感性分析显示，Arg72Pro多态性中，C与G相比（OR = 1.22，95%CI [1.05；1.40]），CC与GG相比（OR = 1.54；95%CI [1.13；2.09]），CC + CG与GG相比（OR = 1.24；95%CI [1.01；1.53]），CC与CG + GG相比（OR = 1.33；95%CI [1.01；1.74]），以及T309G多态性中，G与T相比（OR = 1.30；95%CI [1.07；1.57]），GG与GT + TT相比（OR = 1.53；95%CI [1.10；2.11]），GG与GT相比（OR = 1.44；95%CI [1.02；2.02]），GG与TT相比（OR = 1.88；95%CI [1.25；2.82]）与膀胱癌发生存在显著关联。