Abraham-Aggarwal Kiran, Kacker Ashutosh
School of Industrial and Labor Relations, Cornell University, Ithaca, NY, United States.
Department of Otorhinolaryngology - Head and Neck Surgery, Joan and Sanford I. Weill Medical College, Cornell University, Ithaca, NY, United States.
Int Arch Otorhinolaryngol. 2025 Aug 7;29(3):1-3. doi: 10.1055/s-0045-1801855. eCollection 2025 Jul.
Obstructive sleep apnea (OSA) is a prevalent condition often managed with continuous positive airway pressure (CPAP) treatment. There is an ongoing debate about the link between OSA and cardiovascular disease (CVD), but the existing evidence points toward an association. The present study aims to investigate whether CPAP is an effective strategy to reduce the risk of developing CVD risk among OSA patients. The literature search was conducted in collaboration with Weill Cornell Medical College librarians, and we identified the five most recent papers highlighting the correlation between CPAP treatment for OSA and CVD risk reduction. Recent studies highlight the link between OSA and CVD, emphasizing the potential of the CPAP therapy to reduce the risks of developing CVD and the mortality associated with the condition. The analyses by Guo et al., Peker et al., Khan et al., and Wickwire et al., collectively involving thousands of patients across various study designs, including randomized clinical trials and retrospective cohort studies, consistently demonstrate that the CPAP treatment improves cardiovascular outcomes by lowering blood pressure, reducing sleepiness scores, and significantly decreasing the risk of serious CVD events, especially with consistent adherence to therapy. Although further studies are needed to confirm these findings among patients with consistent high compliance to the CPAP treatment, it remains reasonable to continue to prescribe CPAP as the first-line therapy for OSA due to its potential cardiovascular benefits and low associated risks.
阻塞性睡眠呼吸暂停（OSA）是一种常见病症，通常采用持续气道正压通气（CPAP）治疗。关于OSA与心血管疾病（CVD）之间的联系一直存在争议，但现有证据表明两者存在关联。 本研究旨在调查CPAP是否是降低OSA患者发生CVD风险的有效策略。 文献检索是与威尔康奈尔医学院的图书馆员合作进行的，我们确定了五篇最新论文，突出了OSA的CPAP治疗与降低CVD风险之间的相关性。 最近的研究强调了OSA与CVD之间的联系，强调了CPAP治疗降低发生CVD风险和与该病症相关死亡率的潜力。郭等人、佩克等人、汗等人和威克怀尔等人的分析总共涉及数千名患者，涵盖各种研究设计，包括随机临床试验和回顾性队列研究，一致表明CPAP治疗通过降低血压、降低嗜睡评分以及显著降低严重CVD事件的风险来改善心血管结局，尤其是在持续坚持治疗的情况下。 尽管需要进一步研究来在对CPAP治疗具有持续高依从性的患者中证实这些发现，但由于其潜在的心血管益处和较低的相关风险，继续将CPAP作为OSA的一线治疗方法仍然是合理的。
