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肝缺血再灌注损伤与术后认知功能障碍相关性的生物信息学分析

A bioinformatics analysis of the correlation between hepatic ischemia-reperfusion injury and postoperative cognitive dysfunction.

作者信息

Hu Qing, Liu Haijie, Bao Yunfei, Feng Zhihao, Zhang Hongbo, Li Jianling

机构信息

The Affiliated Hospital of Chengde Medical University, Hebei Province Key Laboratory of Pan-Vascular Diseases Chengde, Hebei, China.

Chengde Medical University, Chengde, China.

出版信息

Front Genet. 2025 Jul 24;16:1607446. doi: 10.3389/fgene.2025.1607446. eCollection 2025.

DOI:10.3389/fgene.2025.1607446
PMID:40778222
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12328142/
Abstract

BACKGROUND

Postoperative cognitive dysfunction (POCD) is a common postoperative complication that is prevalent in elderly people. An increasing number of elderly patients are undergoing surgery. As a result, the number of patients presenting with POCD is increasing. Previous studies have demonstrated that hepatic ischemia-reperfusion injury (HIRI) in mice is associated with postoperative cognitive impairment. Therefore, this study investigated the relationship between POCD and HIRI using bioinformatics research methods.

METHODS

The Gene Expression Omnibus (GEO) database GSE202565 and GeneCards data were selected for correlation analysis using bioinformatics analysis methods. The GSE112713 dataset from the GEO database was chosen for preliminary validation of the screened hub genes.

RESULTS

We analyzed the dataset GSE202565 for differences in gene expression before and after hepatic post-ischemic reperfusion and obtained a total of 53 genes by identifying POCD-related genes. We also screened these 53 genes again and obtained 10 hub genes, which were analyzed and used for correlation prediction. Finally, these 10 hub genes were partially and preliminarily validated using the dataset GSE112713.

CONCLUSION

HIRI is closely related to POCD, and reducing the occurrence of HIRI may become one of the ways to avoid or improve postoperative cognitive impairment in the future.

摘要

背景

术后认知功能障碍（POCD）是一种常见的术后并发症，在老年人中普遍存在。越来越多的老年患者接受手术。因此，出现POCD的患者数量正在增加。先前的研究表明，小鼠肝脏缺血再灌注损伤（HIRI）与术后认知障碍有关。因此，本研究使用生物信息学研究方法探讨了POCD与HIRI之间的关系。

方法

选择基因表达综合数据库（GEO）GSE202565和基因卡片数据，采用生物信息学分析方法进行相关性分析。选择GEO数据库中的GSE112713数据集对筛选出的核心基因进行初步验证。

结果

我们分析了数据集GSE202565中肝脏缺血再灌注前后的基因表达差异，通过鉴定与POCD相关的基因共获得53个基因。我们又对这53个基因进行了筛选，得到10个核心基因，并对其进行分析用于相关性预测。最后，使用数据集GSE112713对这10个核心基因进行了部分初步验证。

结论

HIRI与POCD密切相关，减少HIRI的发生可能成为未来避免或改善术后认知障碍的途径之一。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2265/12328142/d8f947dccce3/fgene-16-1607446-g018.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2265/12328142/d8f947dccce3/fgene-16-1607446-g018.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2265/12328142/9f86372f7adb/fgene-16-1607446-g009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2265/12328142/0f9d32e0d7c9/fgene-16-1607446-g010.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2265/12328142/0969af4fddaa/fgene-16-1607446-g011.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2265/12328142/d8f947dccce3/fgene-16-1607446-g018.jpg

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