Huang Po-Chi, Lin Szu-I, Sun Na-Lee, Li Shu-Yuan, Chen Cheng-Pin, Lin Yi-Chun, Cheng Chien-Yu, Chu Fang-Yeh, Cheng Shu-Hsing
Department of Pathology, Taoyuan General Hospital, Taoyuan, Taiwan.
Department of Dentists, Taoyuan General Hospital, Taoyuan, Taiwan.
J Oral Pathol Med. 2025 Sep;54(8):746-756. doi: 10.1111/jop.70023. Epub 2025 Aug 8.
To detect human papillomavirus (HPV) at oral and anal sites and assess genotype concordance among men who have sex with men (MSM) living with human immunodeficiency virus (HIV) in Taiwan.
HIV-positive men aged 20 years or older attending outpatient clinics at Taoyuan General Hospital, Taiwan, were enrolled. Oral gargle and anal swab samples were collected for HPV genotyping using linear array testing. Multivariate logistic regression identified factors associated with oral-HPV and oral-anal genotype concordance. Significance was set at p < 0.05.
Of 196 eligible participants, the mean age was 32.2 years and over 95% were MSM. The mean CD4+ T cell count was 588 cells/μL (95% confidence interval [CI]: 551-626), and 73% (n = 143) had suppressed viral loads. Anal-HPV was detected in 184 participants (93.8%, 95% CI: 90.5%-97.2%), with 82.7% (n = 162) having oncogenic genotypes. Oral HPV was found in 20 participants (10.2%, 95% CI: 5.9%-14.4%), with 30% (n = 6) having oncogenic genotypes. Among those with oral HPV, 55% (n = 11) showed genotype concordance with anal sites. Only 30% reported condom use during oral sex. Concordance was significantly associated with the number of anal-HPV genotypes (adjusted odds ratio: 1.58, 95% CI: 1.08-2.32, p = 0.015), adjusting for drug use, internet-based partners, recent sexually transmitted infections, and anal oncogenic HPV count.
Oral HPV was common, and over half of the infections matched genotypes found anally. These results support targeted HPV vaccination promotion among MSM living with HIV in Taiwan.
检测台湾地区感染人类免疫缺陷病毒（HIV）的男男性行为者（MSM）口腔和肛门部位的人乳头瘤病毒（HPV），并评估基因型一致性。
招募台湾桃园总医院门诊年龄在20岁及以上的HIV阳性男性。收集口腔含漱液和肛门拭子样本，采用线性阵列检测进行HPV基因分型。多因素逻辑回归分析确定与口腔HPV及口腔-肛门基因型一致性相关的因素。设定显著性水平为p < 0.05。
196名符合条件的参与者中，平均年龄为32.2岁，超过95%为男男性行为者。平均CD4 + T细胞计数为588个/μL（95%置信区间[CI]：551 - 626），73%（n = 143）的病毒载量得到抑制。184名参与者（93.8%，95% CI：90.5% - 97.2%）检测到肛门HPV，其中82.7%（n = 162）为致癌基因型。20名参与者（10.2%，95% CI：5.9% - 14.4%）检测到口腔HPV，其中30%（n = 6）为致癌基因型。在感染口腔HPV的参与者中，55%（n = 11）的基因型与肛门部位一致。只有30%的人报告在口交时使用了避孕套。在调整吸毒、网络性伴、近期性传播感染及肛门致癌HPV数量后，一致性与肛门HPV基因型数量显著相关（调整后的优势比：1.58，95% CI：1.08 - 2.32，p = 0.015）。
口腔HPV感染常见，超过半数感染的基因型与肛门部位一致。这些结果支持在台湾地区对感染HIV的男男性行为者进行有针对性的HPV疫苗推广。
