Schaberg S J, Liboff A R, Falk M C
J Biomed Mater Res. 1985 Jul-Aug;19(6):673-84. doi: 10.1002/jbm.820190607.
Although it has been reported, in observations connected to electrically stimulated bone repair, that intramedullary electrodes not attached to any electrical source can also induce osteogenesis, there has been only one systematic attempt to study this effect per se. We have extended these studies, implanting selected metal and plastic wires longitudinally into the medullary diaphyses of rat femora. Atomic absorption analysis was used for the first time in analyzing for medullary calcium. This technique and the histologic evaluation clearly indicate that osteogenesis occurs within 2 weeks after this wire implantation. Osteogenesis was not observed when the wire was immediately removed after the original trauma of wire insertion.
尽管在与电刺激骨修复相关的观察中已有报道，未连接任何电源的髓内电极也可诱导成骨，但仅有一次系统尝试本身研究这种效应。我们扩展了这些研究，将选定的金属丝和塑料丝纵向植入大鼠股骨的髓腔骨干。首次使用原子吸收分析法分析髓内钙。这项技术和组织学评估清楚地表明，在植入这种金属丝后2周内发生了成骨。在插入金属丝的初始创伤后立即取出金属丝时，未观察到成骨。
