von Frauhofer J A, Polk H C, Seligson D
J Biomed Mater Res. 1985 Sep;19(7):751-6. doi: 10.1002/jbm.820190703.
The in vitro leaching characteristics of tobramycin from acrylic resin (PMMA) bone cement beads have been determined by a radioimmune assay. Tobramycin was incorporated at two concentrations into bone cement beads fabricated from three commercial brands of acrylic resin. Antibiotic leaching followed a curvilinear relationship of the form X . Y = A . X + B . Y. All beads showed similar tobramycin leaching rates over time but the initial amount of leached material differed with the amount of tobramycin incorporated in the bead and the source of the PMMA bone cement. The data indicate that tobramycin-impregnated PMMA beads permit antibiotic leaching at a controlled rate compatible with possible clinical application.
通过放射免疫分析法测定了妥布霉素从丙烯酸树脂（聚甲基丙烯酸甲酯）骨水泥珠中的体外浸出特性。将两种浓度的妥布霉素掺入由三个商业品牌丙烯酸树脂制成的骨水泥珠中。抗生素浸出遵循X.Y = A.X + B.Y形式的曲线关系。所有珠子随着时间推移显示出相似的妥布霉素浸出率，但浸出物质的初始量因掺入珠子中的妥布霉素量以及聚甲基丙烯酸甲酯骨水泥的来源而异。数据表明，妥布霉素浸渍的聚甲基丙烯酸甲酯珠允许抗生素以与可能的临床应用相适应的可控速率浸出。
