基于核因子κB（NF-κB）通路的软骨寡聚基质蛋白（COMP）对骨关节炎样软骨细胞的保护作用 - Suppr

Protective effect of cartilage oligomeric matrix protein (COMP) on osteoarthritis-like chondrocytes based on the nuclear factor kappa B (NF-κB) pathway.

作者信息

Weng Wei, Wu Rong, Sun Zhenguo, Li Haidong, Shen Yuxin, Li Heng, Min Jikang

机构信息

Department of Orthopedics, The First People's Hospital of Huzhou (The First Affiliated Hospital of Huzhou University), Huzhou, 313000, China.

出版信息

J Mol Histol. 2025 Aug 8;56(4):256. doi: 10.1007/s10735-025-10538-9.

DOI:10.1007/s10735-025-10538-9

PMID:40779002

Abstract

摘要

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Protective effect of cartilage oligomeric matrix protein (COMP) on osteoarthritis-like chondrocytes based on the nuclear factor kappa B (NF-κB) pathway.基于核因子κB（NF-κB）通路的软骨寡聚基质蛋白（COMP）对骨关节炎样软骨细胞的保护作用

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Cleavage of Cartilage Oligomeric Matrix Protein (COMP) by ADAMTS4 generates a neoepitope associated with osteoarthritis and other forms of degenerative joint disease.ADAMTS4对软骨寡聚基质蛋白（COMP）的切割产生了一种与骨关节炎和其他形式的退行性关节疾病相关的新表位。

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Protective effect of cartilage oligomeric matrix protein (COMP) on osteoarthritis-like chondrocytes based on the nuclear factor kappa B (NF-κB) pathway.

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