实验性饮食对甲基亚硝基脲诱导的大鼠乳腺癌肝脏谷胱甘肽水平的影响。
Influence of experimental diets on hepatic glutathione levels in rats with methylnitrosourea-induced mammary carcinoma.
作者信息
Aksoy M, Frei E, Berger M R
出版信息
J Cancer Res Clin Oncol. 1985;110(3):244-6. doi: 10.1007/BF00399282.
Abstract
Mammary tumor development induced by methylnitrosourea in female Sprague-Dawley rats had no significant effect on hepatic glutathione levels. If the diets of methylnitrosourea-treated animals were supplemented with vitamin A and E an increased hepatic glutathione level was observed initially. A high fat diet (21% per weight) supplemented with the two vitamins led to a decreased hepatic glutathione level 2 months after tumor induction. Advanced tumor development under any of the diets tested had no effect on hepatic glutathione.
摘要
甲基亚硝基脲诱导雌性斯普拉格-道利大鼠发生乳腺肿瘤，对肝脏谷胱甘肽水平无显著影响。如果给经甲基亚硝基脲处理的动物的饮食补充维生素A和E，最初会观察到肝脏谷胱甘肽水平升高。补充这两种维生素的高脂肪饮食（占体重的21%）在肿瘤诱导2个月后导致肝脏谷胱甘肽水平降低。在所测试的任何一种饮食条件下，晚期肿瘤的发展对肝脏谷胱甘肽均无影响。
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