Tsai Yuan-Jen, Kuo Chia-Min, Hsu Jhih-Wei, Chen Chun-Chang, Lin Chien-Ming, Chen Ying-Chuan, Chen Yang-Ching
Department of Family Medicine, Taipei Medical University Hospital, Taipei Medical University, Taipei, Taiwan.
Department of Family Medicine, School of Medicine, College of Medicine, Taipei Medical University, Taipei, Taiwan.
J Endocrinol Invest. 2025 Aug 8. doi: 10.1007/s40618-025-02677-3.
Central precocious puberty (CPP) is characterized by the early onset of secondary sexual characteristics caused by premature activation of the hypothalamic-pituitary-gonadal axis. CPP can result in short stature, reproductive health complications, and psychosocial challenges. The rising prevalence of CPP underscores the urgency of investigating the genetic and dietary factors that influence its development to reduce long-term health and developmental effects. CPP was diagnosed in 481 participants. Aspartame, sucralose, glycyrrhizin, and added sugars were significantly linked to increased CPP risk, particularly in genetically predisposed individuals. A dose-dependent relationship was also identified, with higher sweetener intake associated with a greater risk of CPP. Gender-specific effects were also discovered, with sucralose being strongly associated with CPP in boys and glycyrrhizin, sucralose, and added sugar all being strongly associated with CPP in girls. The effects of the interaction between genetic predisposition and sweetener intake on this risk were non-significant. Sweetener consumption and high genetic predisposition independently increase the risk of CPP. Therefore, combining genetic and dietary assessments can guide prevention strategies for at-risk children, reducing the long-term health effects of early puberty.
中枢性性早熟（CPP）的特征是下丘脑-垂体-性腺轴过早激活导致第二性征提前出现。CPP可导致身材矮小、生殖健康并发症和心理社会挑战。CPP患病率的上升凸显了研究影响其发展的遗传和饮食因素以减少长期健康和发育影响的紧迫性。481名参与者被诊断为CPP。阿斯巴甜、三氯蔗糖、甘草甜素和添加糖与CPP风险增加显著相关，尤其是在有遗传易感性的个体中。还发现了剂量依赖关系，甜味剂摄入量越高，CPP风险越大。还发现了性别特异性影响，三氯蔗糖与男孩的CPP密切相关，而甘草甜素、三氯蔗糖和添加糖与女孩的CPP均密切相关。遗传易感性和甜味剂摄入量之间的相互作用对这种风险的影响不显著。甜味剂消费和高遗传易感性独立增加CPP风险。因此，结合遗传和饮食评估可以指导对高危儿童的预防策略，减少青春期提前带来的长期健康影响。
