Host-induced climate change: Carbon dioxide tolerance as a Cryptococcus neoformans virulence trait.

作者信息

Blackburn Emma E, Ristow Laura C, Lin Xiaorong, Krysan Damian J

机构信息

Department of Microbiology, University of Georgia, Athens, Georgia, United States of America.

Department of Pediatrics, Carver College of Medicine, University of Iowa, Iowa City, Iowa, United States of America.

出版信息

PLoS Pathog. 2025 Aug 8;21(8):e1013351. doi: 10.1371/journal.ppat.1013351. eCollection 2025 Aug.

DOI:10.1371/journal.ppat.1013351

PMID:40779504

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12333976/

Abstract

摘要

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c7a2/12333976/11d6b4ac34e3/ppat.1013351.g001.jpg

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本文引用的文献

[1]

Microevolution of Cryptococcus neoformans in high CO converges on mutations isolated from patients with relapsed cryptococcosis.

Cell Rep. 2025-3-25

[2]

Discovery of CO tolerance genes associated with virulence in the fungal pathogen Cryptococcus neoformans.

Nat Microbiol. 2024-10

[3]

Cryptococcus neoformans adapts to the host environment through TOR-mediated remodeling of phospholipid asymmetry.

Nat Commun. 2023-10-18

[4]

The hypothermic nature of fungi.

Proc Natl Acad Sci U S A. 2023-5-9

[5]

The RAM signaling pathway links morphology, thermotolerance, and CO tolerance in the global fungal pathogen .

Elife. 2022-11-23

[6]

Global guideline for the diagnosis and management of the endemic mycoses: an initiative of the European Confederation of Medical Mycology in cooperation with the International Society for Human and Animal Mycology.

Lancet Infect Dis. 2021-12

[7]

Repeated Evolution of Inactive Pseudonucleases in a Fungal Branch of the Dis3/RNase II Family of Nucleases.

Mol Biol Evol. 2021-5-4

[8]

Host Carbon Dioxide Concentration Is an Independent Stress for Cryptococcus neoformans That Affects Virulence and Antifungal Susceptibility.

mBio. 2019-7-2

[9]

The TOR Pathway Plays Pleiotropic Roles in Growth and Stress Responses of the Fungal Pathogen .

Genetics. 2019-6-7

[10]

The Mouse Inhalation Model of Infection Recapitulates Strain Virulence in Humans and Shows that Closely Related Strains Can Possess Differential Virulence.

Infect Immun. 2019-4-23

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Host-induced climate change: Carbon dioxide tolerance as a Cryptococcus neoformans virulence trait.

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