Iriarte Evelyn, Jones Raymond, Wang Crystal X, Hall Casey D Xavier, Byun Jun Y, Krause Kristen D, Kohli Maulika, Erlandson Kristine M, Sundermann Erin, Moore David J, Letendre Scott, Ellis Ronald J
College of Nursing, University of Colorado Anschutz Medical Campus, Aurora, CO, USA.
Heersink School of Medicine, University of Alabama at Birmingham, AL, USA.
AIDS. 2025 Aug 8. doi: 10.1097/QAD.0000000000004312.
Examine the associations of gait speed with global and domain-specific neurocognition in older people with HIV (PWH) versus people without HIV (PWoH).
Participants included 285 PWH and 214 PWoH 50 years and older (Mage= 60.1, SD age=7.1) who completed a gait examination and a comprehensive neurocognitive assessment.
Gait speed was significantly slower in PWH (M=3.3 s, SD=1.1) than PWoH (M = 3.0 s, SD = 0.9; p = .006). Slower gait speed was significantly associated with poorer global neurocognition (β= -0.17, p = .009) and deficits in multiple neurocognitive domains, including verbal fluency, executive functioning, processing speed, and motor skills, after adjusting for sociodemographic, HIV-related, and medical characteristics in PWH. A significant interaction between gait speed and HIV status emerged for verbal fluency, suggesting differential cognitive impacts (β=-0.45, p = .008).
Our findings highlight nuanced relationships between gait speed and neurocognition, emphasizing the need for longitudinal research to establish causal mechanisms and potential clinical screening approaches.
研究人类免疫缺陷病毒感染者（PWH）与未感染人类免疫缺陷病毒者（PWoH）中，步态速度与整体及特定领域神经认知之间的关联。
参与者包括285名年龄在50岁及以上的PWH和214名PWoH（年龄均值=60.1，年龄标准差=7.1），他们完成了步态检查和全面的神经认知评估。
PWH的步态速度（均值=3.3秒，标准差=1.1）显著慢于PWoH（均值=3.0秒，标准差=0.9；p=0.006）。在对PWH的社会人口统计学、HIV相关和医学特征进行调整后，较慢的步态速度与较差的整体神经认知（β=-0.17，p=0.009）以及多个神经认知领域的缺陷显著相关，包括语言流畅性、执行功能、处理速度和运动技能。在语言流畅性方面，步态速度与HIV状态之间出现了显著的交互作用，表明存在不同的认知影响（β=-0.45，p=0.008）。
我们的研究结果突出了步态速度与神经认知之间的细微关系，强调需要进行纵向研究以建立因果机制和潜在的临床筛查方法。
