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井上-梅尔尼克病毒及抗体在脑脊液中的持续存在情况。

Persistence of Inoue-Melnick virus and antibody in cerebrospinal fluid.

作者信息

Melnick J L, Seidel E, Wang S S, Muchinik G, Rashti E J, Jacobs L D, Freeman A I, O'Malley J

出版信息

J Clin Microbiol. 1985 Oct;22(4):651-3. doi: 10.1128/jcm.22.4.651-653.1985.

Abstract

Serial cerebrospinal fluid samples were obtained from 14 multiple sclerosis patients over a period of several months and were tested under code for Inoue-Melnick virus. In five of the positive patients, virus was present in 28 of 32 specimens collected over a period of 2 to 5 months. Four patients, from whom a total of 34 specimens were taken, yielded only a single isolate each. Five patients contributed 28 specimens, all of which were negative. In six patients (three virus positive and three virus negative), neutralizing antibody was detected in serum and in cerebrospinal fluid.

摘要

在几个月的时间里,从14名多发性硬化症患者身上采集了系列脑脊液样本,并对其进行编码,检测是否存在井上 - 梅尔尼克病毒。在5名阳性患者中,在2至5个月期间采集的32份标本中有28份检测到病毒。4名患者共提供了34份标本,每人仅分离出1株病毒。5名患者提供了28份标本,所有标本均为阴性。在6名患者(3名病毒阳性和3名病毒阴性)中,在血清和脑脊液中检测到中和抗体。

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