Thompson J A, Bray P F, Glasgow L A
Neurology. 1975 Jan;25(1):94-6. doi: 10.1212/wnl.25.1.94.
Thirty percent of 33 patients with a clinical diagnosis of multiple sclerosis and an elevation of cerebrospinal fluid (CSF) immunoglobulin G/albumin ratio greater than 2 standard deviations above the mean had elevation of the CSF vaccinia neutralizing antibody titer. Elevated titers were found in 1 of 23 patients with non-multiple sclerosis neurologic diseases and in none of the normal control patients. No linear correlation was found between the magnitude of the relative or absolute CSF immunoglobulin G concentration and the magnitude of the CSF vaccinia neutralizing antibody titers.
临床诊断为多发性硬化且脑脊液（CSF）免疫球蛋白G/白蛋白比值高于均值2个标准差以上的33例患者中，30%的患者脑脊液牛痘中和抗体滴度升高。23例非多发性硬化神经系统疾病患者中有1例滴度升高，正常对照患者中无一例升高。脑脊液相对或绝对免疫球蛋白G浓度与脑脊液牛痘中和抗体滴度之间未发现线性相关性。
