Nasr Mahmoud, Piórkowski Adam, Brzostowski Krzysztof, El-Samie Fathi E Abd
Department of Biocybernetics and Biomedical Engineering, AGH University of Krakow, Krakow, Poland; Sano Centre for Computational Medicine, Krakow, Poland.
Department of Biocybernetics and Biomedical Engineering, AGH University of Krakow, Krakow, Poland.
Comput Biol Med. 2025 Sep;196(Pt C):110644. doi: 10.1016/j.compbiomed.2025.110644. Epub 2025 Aug 7.
Denoising reconstructed Computed Tomography (CT) images without access to raw projection data remains a significant difficulty in medical imaging, particularly when utilizing sharp or medium reconstruction kernels that generate high-frequency noise. This work introduces an innovative method that integrates quaternion mathematics with bilateral filtering to resolve this issue. The proposed Quaternion Bilateral Filter (QBF) effectively maintains anatomical structures and mitigates noise caused by the kernel by expressing CT scans in quaternion form, with the red, green, and blue channels encoded together. Compared to conventional methods that depend on raw data or grayscale filtering, our approach functions directly on reconstructed sharp kernel images. It converts them to mimic the quality of soft-kernel outputs, obtained with kernels such as B30f, using paired data from the same patients. The efficacy of the QBF is evidenced by both full-reference metrics (Structural Similarity Index Measure (SSIM), Peak Signal-to-Noise Ratio (PSNR), Mean Absolute Error (MAE), and Root Mean Squared Error (RMSE)) and no-reference perceptual metrics (Naturalness Image Quality Evaluator (NIQE), Blind Referenceless Image Spatial Quality Evaluator (BRISQUE), and Perception-based Image Quality Evaluator (PIQE)). The results indicate that the QBF demonstrates improved denoising efficacy compared to traditional Bilateral Filter (BF), Non-Local Means (NLM), wavelet, and Convolutional Neural Network (CNN)-based processing, achieving an SSIM of 0.96 and a PSNR of 36.3 on B50f reconstructions. Additionally, segmentation-based visual validation verifies that QBF-filtered outputs maintain essential structural details necessary for subsequent diagnostic tasks. This study emphasizes the importance of quaternion-based filtering as a lightweight, interpretable, and efficient substitute for deep learning models in post-reconstruction CT image enhancement.
在无法获取原始投影数据的情况下对重建的计算机断层扫描(CT)图像进行去噪,在医学成像中仍然是一个重大难题,尤其是在使用会产生高频噪声的锐利或中等重建核时。这项工作引入了一种创新方法,将四元数数学与双边滤波相结合来解决这个问题。所提出的四元数双边滤波器(QBF)通过以四元数形式表示CT扫描,将红色、绿色和蓝色通道一起编码,有效地保持了解剖结构并减轻了由核引起的噪声。与依赖原始数据或灰度滤波的传统方法相比,我们的方法直接作用于重建的锐利核图像。它使用来自同一患者的配对数据将它们转换为模拟使用诸如B30f等核获得的软核输出的质量。全参考指标(结构相似性指数测量(SSIM)、峰值信噪比(PSNR)、平均绝对误差(MAE)和均方根误差(RMSE))以及无参考感知指标(自然度图像质量评估器(NIQE)、盲无参考图像空间质量评估器(BRISQUE)和基于感知的图像质量评估器(PIQE))都证明了QBF的有效性。结果表明,与传统双边滤波器(BF)、非局部均值(NLM)、小波和基于卷积神经网络(CNN)的处理相比,QBF表现出更高的去噪效果,在B50f重建上实现了0.96的SSIM和36.3的PSNR。此外,基于分割的视觉验证证实,经QBF滤波的输出保留了后续诊断任务所需的基本结构细节。这项研究强调了基于四元数的滤波作为重建后CT图像增强中深度学习模型的轻量级、可解释且高效替代方法的重要性。