通过新生儿筛查诊断并接受左甲状腺素治疗的先天性甲状腺功能减退症患儿肥胖反弹的时间。

Timing of adiposity rebound in children with congenital hypothyroidism diagnosed by newborn screening and treated with Levothyroxine.

作者信息

Lugarà Cecilia, Corica Domenico, Pepe Giorgia, Messina Maria Francesca, Valenzise Mariella, Zirilli Giuseppina, Morabito Letteria Anna, Li Pomi Alessandra, Wasniewska Malgorzata Gabriela, Aversa Tommaso

机构信息

Department of Human Pathology of Adulthood and Childhood, University of Messina, Via Consolare Valeria, Messina, 98124, Italy.

Pediatric Unit, "G. Martino" University Hospital, Via Consolare Valeria, Messina, 98124, Italy.

出版信息

Ital J Pediatr. 2025 Aug 8;51(1):249. doi: 10.1186/s13052-025-02099-0.

DOI:10.1186/s13052-025-02099-0

PMID:40781336

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12333145/

Abstract

BACKGROUND

Children with congenital hypothyroidism (CH) are at increased risk of developing childhood obesity. Moreover, an adiposity rebound (AR) that occur early is strongly linked with future obesity. The aims of our study were to explore the timing of AR, to identify factors affecting AR and correlation between age and body mass index (BMI) at AR and BMI at eight years of age in children with CH.

METHODS

A retrospective, observational study was conducted on Caucasian children with CH. For each child, BMI growth curve was constructed, AR was identified and compared with the Italian national and regional references.

RESULTS

Sixty-nine patients (44 females) were recruited. The age at AR was 3.4 ± 1.2 vs. 4.5 years of the comparison population ( < 0.001) in females and 3.4 ± 1.4 vs. 5.0 years of the comparison population ( < 0.001) in males with CH. Age at AR showed a significant negative correlation with BMI at 8 years ( = − 0.274, < 0.039). BMI at AR and BMI at 8 years of age correlated positively ( = 0.460, < 0.001). The prevalence of obesity/overweight at 8 years of age was 30%. BMI at 8 years of age was 22.4 ± 1.8 kg/m in overweight/obese subgroup and 16.9 ± 1.8 kg/m in normal BMI subgroup ( 0.001).

CONCLUSION

Children with CH showed earlier AR compared to Italian national references. The higher risk of obesity in patients with early AR is supported by the association between age, BMI at AR, and BMI at eight years.

摘要

背景

先天性甲状腺功能减退症（CH）患儿患儿童肥胖症的风险增加。此外，早期出现的肥胖反弹（AR）与未来肥胖密切相关。我们研究的目的是探讨CH患儿AR的发生时间，确定影响AR的因素，以及AR时的年龄与体重指数（BMI）和8岁时BMI之间的相关性。

方法

对白人CH患儿进行了一项回顾性观察研究。为每个患儿构建BMI生长曲线，确定AR并与意大利国家和地区参考标准进行比较。

结果

招募了69例患者（44例女性）。CH女性患儿AR的年龄为3.4±1.2岁，而对照人群为4.5岁（P<0.001）；CH男性患儿AR的年龄为3.4±1.4岁，对照人群为5.0岁（P<0.001）。AR时的年龄与8岁时的BMI呈显著负相关（r=-0.274，P<0.039）。AR时的BMI与8岁时的BMI呈正相关（r=0.460，P<0.001）。8岁时肥胖/超重的患病率为30%。超重/肥胖亚组8岁时的BMI为22.4±1.8kg/m²，正常BMI亚组为16.9±1.8kg/m²（P<0.001）。