Shukla Ajay Kumar, Jhaj Ratinder, Atal Shubham, Majumdar Anindo, Meena Mahadev, Tiwari Sandeep, Siddiqui Bushra, Cherian Jerin Jose, Faruqui Atiya R, Sabu Sowparnika Treasa
Department of Pharmacology, AIIMS, Bhopal, Madhya Pradesh, 462020, India.
Department of CFM, AIIMS, Bhopal, 462020, India.
Syst Rev. 2025 Aug 8;14(1):163. doi: 10.1186/s13643-025-02884-2.
Among the elderly, who are often exposed to polypharmacy, explicit deprescribing tools offer clear, validated guidelines for safely reducing medications. However, the effectiveness of these tools varies across healthcare settings and populations. In India, unique sociocultural and healthcare challenges demand a tailored approach to deprescribing for elderly patients, and the need to adapt existing tools to local contexts. The primary objective of this scoping review is mapping of the contextual relevance and applicability of the existing explicit deprescribing tools for elderly population in Indian healthcare settings.
The scoping review will be carried out in six stages: (1) Identifying the review question. (2) Identifying relevant studies through electronic databases (i.e., PubMed, Web of Science, and Embase). (3) Selection of studies to be included based on inclusion and exclusion criteria. Inclusion criteria for this scoping review are studies implementing explicit deprescribing tools involving Indian elderly patients, reporting on outcomes, validation methods, or contextual relevance of deprescribing tools, published in English or non-English language with English translation available. Exclusion criteria for this scoping review are studies focused on implicit deprescribing tools, review articles, case reports, commentaries, and editorials. Two independent reviewers will conduct the search and initial screening of studies. Discrepancies will then be solved through discussion with the third reviewer. (4) Charting, categorizing, and thematic analysis of the extracted data. (5) Collating, summarizing, and reporting the results. (6) Dissemination of findings.
By reviewing the patient population and study setting of studies of explicit tools in India, vis a vis the healthcare setting and patient population for which the tool was designed, our scoping review highlighted the strengths and weaknesses in the existing literature. These findings could be used to direct future research and assess the need for a deprescribing tool adapted for the Indian elderly patients.
在经常使用多种药物的老年人中,明确的减药工具为安全减少用药提供了清晰、经过验证的指南。然而,这些工具的有效性在不同的医疗环境和人群中有所不同。在印度,独特的社会文化和医疗挑战要求针对老年患者采用量身定制的减药方法,并且需要使现有工具适应当地情况。本范围综述的主要目的是梳理现有明确的减药工具在印度医疗环境中对老年人群的背景相关性和适用性。
范围综述将分六个阶段进行:(1)确定综述问题。(2)通过电子数据库(即PubMed、科学网和Embase)识别相关研究。(3)根据纳入和排除标准选择要纳入的研究。本范围综述的纳入标准是实施涉及印度老年患者的明确减药工具的研究,报告减药工具的结果、验证方法或背景相关性,以英文或有英文翻译的非英文语言发表。本范围综述的排除标准是专注于隐性减药工具的研究、综述文章、病例报告、评论和社论。两名独立评审员将进行研究的检索和初步筛选。然后通过与第三名评审员讨论解决分歧。(4)对提取的数据进行图表绘制、分类和主题分析。(5)整理、总结和报告结果。(6)传播研究结果。
通过对比印度明确工具研究的患者群体和研究环境与该工具所设计的医疗环境和患者群体,我们的范围综述突出了现有文献中的优势和不足。这些发现可用于指导未来的研究,并评估是否需要为印度老年患者量身定制减药工具。