虚拟现实干预在酒精使用障碍评估与治疗中的应用——关于方法学的系统综述

Virtual reality interventions in the assessment and treatment of alcohol use disorder - a systematic scoping review on methodology.

作者信息

Gaddum Olivia, Gutwinski Stefan, Lütt Alva, Moon Daa Un, Beck Anne, Ruckser Nadja, Turno Alessandro, Schöneck Robert, Bermpohl Felix, Tsamitros Nikolaos

机构信息

Department of Psychiatry and Neurosciences, Campus Charité Mitte Charité - Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humboldt Universität zu Berlin, Berlin, Germany.

Department of Radiology and Biomedical Imaging, Yale University School of Medicine, 300 Cedar St, New Haven, CT, 06520, USA.

出版信息

Addict Sci Clin Pract. 2025 Aug 8;20(1):64. doi: 10.1186/s13722-025-00587-6.

Abstract

BACKGROUND

Virtual reality (VR) technology has been increasingly employed to develop innovative treatments for Alcohol use disorder (AUD) and overcome limitations of currents therapies. However, previous research in this field has yielded inconclusive results. To improve the quality and comparability of studies, a critical analysis of the research methodology employed in this field is necessary.

OBJECTIVES

This scoping review aims to provide an overview of existing studies with a focus on their objectives, methodology, treatment paradigms, and VR design characteristics.

METHODS

A systematic literature research was conducted in the electronic databases MEDLINE (PubMed), APA PsychInfo, APA PsychArticles, PSYINDEX (EBSCOhost), Scopus, Web of Science and by search in the reference list of included publication to identify relevant publications. Clinical studies and study protocols using VR for the assessment or treatment of patients with AUD were included.

RESULTS

The literature search yielded 1.197 studies, of which 22 met the inclusion criteria. Completed trials (n = 16) and study protocols (n = 6) were included. The majority of the studies (n = 19) used a VR cue exposure paradigm to induce craving. The studies can be classified either as assessment (n = 9) or treatment studies (n = 13). The duration (7-60 min) and number of applied sessions (1-13) varied significantly depending on the type of study. Craving outcomes were based on subjective and physiological measurements. All studies used alcoholic beverages and VR scenarios such as bars, pubs, parties and restaurants, with additional scenarios varying, except for one study using a hospital and subway scenario as aversive scenarios. Moreover, synchronized olfactory stimuli were frequently used.

CONCLUSIONS

Despite the heterogeneity of VR software features and VR interventions, it was possible to identify a similarity within the main VR scenarios employed, as well as consistent positive results concerning the induction of subjective craving by alcohol-associated VR cues. While VR interventions for AUD show methodological progress, future research should adopt standardized protocols, include objective psychophysiological outcomes, and evaluate long-term efficacy and feasibility in clinical settings. Integration of emerging VR paradigms and technologies may further enhance the therapeutic potential.

摘要

背景

虚拟现实(VR)技术已越来越多地用于开发酒精使用障碍(AUD)的创新治疗方法,并克服现有疗法的局限性。然而,该领域先前的研究结果尚无定论。为提高研究的质量和可比性,有必要对该领域所采用的研究方法进行批判性分析。

目的

本综述旨在概述现有研究,重点关注其目标、方法、治疗范式和VR设计特征。

方法

在电子数据库MEDLINE(PubMed)、美国心理学会心理学文摘数据库(APA PsychInfo)、美国心理学会心理学期刊全文数据库(APA PsychArticles)、心理学文摘索引数据库(PSYINDEX,EBSCOhost)、Scopus数据库、科学引文索引数据库(Web of Science)中进行系统的文献检索,并通过搜索纳入出版物的参考文献列表来识别相关出版物。纳入使用VR评估或治疗AUD患者的临床研究和研究方案。

结果

文献检索共获得1197项研究,其中22项符合纳入标准。纳入了已完成的试验(n = 16)和研究方案(n = 6)。大多数研究(n = 19)采用VR线索暴露范式来诱发渴望。这些研究可分为评估研究(n = 9)或治疗研究(n = 13)。根据研究类型的不同,持续时间(7 - 60分钟)和应用疗程数(1 - 13)差异很大。渴望结果基于主观和生理测量。所有研究均使用酒精饮料和酒吧、酒馆、派对和餐厅等VR场景,除了一项研究使用医院和地铁场景作为厌恶场景外,其他额外场景各不相同。此外,同步嗅觉刺激也经常被使用。

结论

尽管VR软件功能和VR干预存在异质性,但仍有可能识别出所采用的主要VR场景中的相似性,以及酒精相关VR线索诱发主观渴望方面一致的积极结果。虽然针对AUD的VR干预显示出方法学上的进展,但未来的研究应采用标准化方案,纳入客观的心理生理结果,并评估临床环境中的长期疗效和可行性。新兴VR范式和技术的整合可能会进一步提高治疗潜力。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b9e2/12333255/b3265ed80fb7/13722_2025_587_Fig1_HTML.jpg

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