Lin Yipeng, Wang Janney Z, Niu Yihe, Zhu Ling, Duke Rujee K, Duke Colin C, Murray Michael, Zhou Fanfan
Molecular Drug Development Group, Sydney Pharmacy School, Faculty of Medicine and Health, The University of Sydney, Sydney, New South Wales, Australia.
Macular Research Group, Save Sight Institute, Faculty of Medicine and Health, The University of Sydney, Sydney, New South Wales, Australia.
Phytother Res. 2025 Sep;39(9):4230-4246. doi: 10.1002/ptr.70029. Epub 2025 Aug 9.
Propolis is a plant-derived substance collected by honeybees that has a range of potential therapeutic applications. Propolis consists of resins, waxes, and fatty acids, as well as essential oils and other organic compounds. The pharmacologically active components of propolis include phenols and flavonoids, among others. Flavonoids that are found in propolis include chrysin, quercetin, galangin, kaempferol, and apigenin. Angiogenesis is the growth of new blood vessels from endothelial cell precursors. Angiogenesis is important in normal physiology and development. Pathological angiogenesis is widely implicated in human diseases, such as retinal diseases, cancers, and inflammatory diseases; currently, many of these conditions lack effective treatments. The process of angiogenesis is modulated by pro-angiogenic factors, in particular, Vascular Endothelial Growth Factor (VEGF). Flavonoids, including several that are present in propolis, have been found to inhibit angiogenesis by attenuating VEGF signaling. Although promising, such findings are primarily based on preclinical studies, and few clinical studies have evaluated the efficacy and toxicity of flavonoids in vivo. This review outlines the therapeutic potential of essential flavonoids from propolis that may have value as anti-angiogenic agents by modulating VEGF signaling. Overall, the findings suggest that flavonoids that are present in propolis are potential agents for the treatment of human diseases in which pathological angiogenesis is activated.
蜂胶是蜜蜂采集的一种植物源物质，具有一系列潜在的治疗应用。蜂胶由树脂、蜡、脂肪酸以及精油和其他有机化合物组成。蜂胶的药理活性成分包括酚类和黄酮类等。蜂胶中发现的黄酮类包括白杨素、槲皮素、高良姜素、山奈酚和芹菜素。血管生成是指从内皮细胞前体生长出新的血管。血管生成在正常生理和发育过程中很重要。病理性血管生成广泛涉及人类疾病，如视网膜疾病、癌症和炎症性疾病；目前，许多这些疾病缺乏有效的治疗方法。血管生成过程由促血管生成因子调节，特别是血管内皮生长因子（VEGF）。已发现黄酮类，包括蜂胶中存在的几种黄酮类，可通过减弱VEGF信号传导来抑制血管生成。尽管前景广阔，但这些发现主要基于临床前研究，很少有临床研究评估黄酮类在体内的疗效和毒性。本综述概述了蜂胶中必需黄酮类的治疗潜力，这些黄酮类可能通过调节VEGF信号传导而具有作为抗血管生成剂的价值。总体而言，研究结果表明，蜂胶中存在的黄酮类是治疗病理性血管生成被激活的人类疾病的潜在药物。
