Munday R
J Appl Toxicol. 1985 Dec;5(6):409-13. doi: 10.1002/jat.2550050614.
Diphenyl disulphide has been shown to generate hydrogen peroxide in erythrocytes in vitro. It also induces oxidative damage (reversible and irreversible haemoglobin oxidation, depletion of non-protein and protein-bound thiols) in these cells. Such changes were also recorded in erythrocytes exposed to 4,4'-diaminodiphenyl disulphide, 2,2'-diaminodiphenyl disulphide, 4,4'-dimethyldiphenyl disulphide, 4,4'-dinitrodiphenyl disulphide, diphenyl disulphide-2,2'-dicarboxylic acid and dibenzyl disulphide. The relative potency of these compounds in causing erythrocyte damage is correlated with their ability to generate 'active oxygen' species in vitro.
二苯基二硫化物已被证明在体外能在红细胞中产生过氧化氢。它还会在这些细胞中诱导氧化损伤（可逆和不可逆的血红蛋白氧化、非蛋白质和蛋白质结合硫醇的消耗）。在暴露于4,4'-二氨基二苯基二硫化物、2,2'-二氨基二苯基二硫化物、4,4'-二甲基二苯基二硫化物、4,4'-二硝基二苯基二硫化物、二苯基二硫化物-2,2'-二羧酸和二苄基二硫化物的红细胞中也记录到了此类变化。这些化合物导致红细胞损伤的相对效力与其在体外产生“活性氧”的能力相关。
