Mozammal Hossain M D, Lee Hyungseok
Dept. Mechanical and Biomedical, Mechatronics Engineering, Kangwon National University (KNU), Chuncheon Campus, Gangwon State 24341, Republic of Korea.
Dept. Mechanical and Biomedical, Mechatronics Engineering, Kangwon National University (KNU), Chuncheon Campus, Gangwon State 24341, Republic of Korea.
Int J Biol Macromol. 2025 Sep;322(Pt 3):146667. doi: 10.1016/j.ijbiomac.2025.146667. Epub 2025 Aug 7.
Bioprinting (BP) technology has played a significant role in the production of organ fabrication with decorated biomaterial and their application in various field, including tissue engineering (TE). BP is an advanced technology that provides the possibility to replicate complex microarchitecture of native tissues through the printing of live cells of cell-laden inks, the so-called bioinks. The engineering of novel bioink formulations with adequate properties such as biocompatibility, biodegradability, high mechanical integrity, and dimensional stability are important in the success of the BP process. Among the various types of bioinks, hydrogels have various similarities with the extracellular matrix that provide good tenability, adhesion, and cell proliferation. Hydrogels in BP technologies represent a modern concept architecture called 3D scaffolds, which support cell growth and assembly in TE. In the development of novel bioinks, polysaccharides (PSs) materials play a crucial role in BP for the applications in TE. Stimuli-responsive materials and methods are considered the major key to achieving the challenge in various fields. Thus, the synergistic interplay of BP technologies and artificial intelligence (AI) has extended the design space and accelerated the design phase that could push more forward. This review summarizes the significance advanced of BP technology. Then there will be discussed the potential of PSs materials and their application in various fields. Additionally, a viewpoint on how the synergistic use of BP and AI can improve the design of intelligent systems with applications ranging from the bioengineering sectors to robotics. Finally, the underlying potential benefits, limitations, and challenges, as well as the prospects for future studies are addressed.
生物打印（BP）技术在带有修饰生物材料的器官制造及其在包括组织工程（TE）在内的各个领域的应用中发挥了重要作用。生物打印是一项先进技术，它通过打印负载细胞的墨水（即所谓的生物墨水）中的活细胞，提供了复制天然组织复杂微结构的可能性。设计具有生物相容性、生物降解性、高机械完整性和尺寸稳定性等适当特性的新型生物墨水配方对于生物打印过程的成功至关重要。在各种类型的生物墨水中，水凝胶与细胞外基质有诸多相似之处，能提供良好的韧性、粘附性和细胞增殖能力。生物打印技术中的水凝胶代表了一种称为3D支架的现代概念架构，它在组织工程中支持细胞生长和组装。在新型生物墨水的开发中，多糖（PSs）材料在用于组织工程的生物打印中起着关键作用。刺激响应材料和方法被认为是应对各个领域挑战的主要关键。因此，生物打印技术与人工智能（AI）的协同相互作用扩展了设计空间并加速了设计阶段，从而可以进一步推动发展。本综述总结了生物打印技术的重要进展。然后将讨论多糖材料的潜力及其在各个领域的应用。此外，还将探讨生物打印与人工智能的协同使用如何改进从生物工程领域到机器人技术等应用的智能系统设计。最后，阐述了潜在的益处、局限性和挑战以及未来研究的前景。
