Schildroth Samantha, Gaston Symielle A, Harmon Quaker E, Jackson Chandra L, Wesselink Amelia K, Wegienka Ganesa, Baird Donna D, Wise Lauren A
Department of Epidemiology, Boston University School of Public Health, Boston, Massachusetts.
Epidemiology Branch, National Institute of Environmental Health Sciences, Durham, North Carolina.
Fertil Steril. 2025 Aug 7. doi: 10.1016/j.fertnstert.2025.08.002.
To investigate associations between hair dye use and incident uterine leiomyomata (fibroids) among Black participants from the Study of Environment, Lifestyle, and Fibroids.
Prospective cohort study.
Reproductive-aged (26-39 years) individuals with an intact uterus residing in the Detroit, Michigan area (n = 868).
Self-reported hair dye use (any use vs. no use) in the previous 12 months queried on structured questionnaires.
Fibroid incidence assessed by transvaginal ultrasounds. We fit Cox proportional hazard models to estimate hazard ratios (HRs) with 95% confidence intervals (CIs), adjusting for age, time in study, educational attainment, annual household income, occupational status, body mass index, age at menarche, parity, use of progestin-only injectable contraceptives within the past 2 years, alcohol consumption, and smoking status.
One hundred and forty nine incident fibroid cases were identified over 3,458 person-years of follow-up. After adjustment for confounders, use of any hair dye product (HR = 1.44; 95% CI = 0.91, 2.26) and rinses that fade (HR = 1.98; 95% CI = 1.04, 3.79) in the previous 12 months was associated with increased fibroid risk, compared with no use, although associations were generally imprecise.
In this cohort, use of hair dye products was modestly associated with a higher fibroid risk, which has important public health implications.
在环境、生活方式与子宫肌瘤研究中，调查黑人参与者使用染发剂与子宫肌瘤发病之间的关联。
前瞻性队列研究。
居住在密歇根州底特律地区的子宫完整的育龄（26 - 39岁）个体（n = 868）。
通过结构化问卷询问过去12个月内自我报告的染发剂使用情况（使用与否）。
经阴道超声评估子宫肌瘤发病率。我们采用Cox比例风险模型来估计风险比（HRs）及其95%置信区间（CIs），并对年龄、研究时间、教育程度、家庭年收入、职业状况、体重指数、初潮年龄、生育次数、过去2年内仅使用孕激素注射避孕药的情况、饮酒量和吸烟状况进行了调整。
在3458人年的随访中，共识别出149例子宫肌瘤发病病例。在对混杂因素进行调整后，与未使用染发剂相比，过去12个月内使用任何染发剂产品（HR = 1.44；95% CI = 0.91，2.26）以及使用褪色洗发水（HR = 1.98；95% CI = 1.04，3.79）与子宫肌瘤风险增加相关，尽管关联通常不太精确。
在该队列中，使用染发剂产品与较高的子宫肌瘤风险存在适度关联，这具有重要的公共卫生意义。
