Pankaj R, Lal S, Rao R S
Indian J Lepr. 1985 Apr-Jun;57(2):329-33.
Serum Rifampicin levels were determined by a microbiological assay using Staphylococcus aureus in 22 cases of leprosy after administering the drug with and without probenecid. Most of the patients showed higher serum rifampicin levels when probenecid was given along with rifampicin. Six patients showed statistically significant increase in the serum levels of the drug when given in the dose of 300 mg along with 1 g of probenecid one hour before breakfast and these levels were comparable with those obtained following administration of 450 mg of rifampicin alone two hours after breakfast. Thus administration of probenecid preceding rifampicin may be employed to reduce cost of drug as well as hepatotoxicity in patients requiring rifampicin for long duration.
在22例麻风患者中，在服用利福平（有或没有丙磺舒）后，通过使用金黄色葡萄球菌的微生物测定法测定血清利福平水平。大多数患者在利福平与丙磺舒一起给药时血清利福平水平较高。6例患者在早餐前1小时给予300mg利福平与1g丙磺舒时，药物血清水平有统计学显著升高，这些水平与早餐后2小时单独给予450mg利福平后获得的水平相当。因此，在需要长期服用利福平的患者中，在利福平之前给予丙磺舒可用于降低药物成本以及肝毒性。
