Petrykina Z M, Bulgakova V G, Polin A N, Silaev A B
Antibiotiki. 1977 Apr;22(4):353-6.
Neotelomycin induced lysis of the protoplasts of Bac. megaterium and inhibited their succinate dehydrogenase activity. Direct correlation between the lytic activity of the antibiotic and its effect on succinate dehydrogenase was found. Neotelomycin had no effect on the dehydrogenase activity of the protoplast lysates. Possibly, suppression of the protoplast succinate dehydrogenase of Bac. megaterium under the effect of neotelomycin was due to significant structural changes caused by the antibiotic in the protoplast membranes and leading to their lysis and not to the direct effect on the enzyme. Neotelomycin had practically no effect on the spheroplast dehydrogenase activity of E. coli resistant to the antibiotic and did not induce their lysis. Resistance of E. coli to neotelomycin must be associated not with the presence of the antibiotic non-permeable cell wall but the peculiar properties of the membrane cytoplasm.
新替米星可诱导巨大芽孢杆菌原生质体裂解，并抑制其琥珀酸脱氢酶活性。发现该抗生素的裂解活性与其对琥珀酸脱氢酶的作用之间存在直接相关性。新替米星对原生质体裂解物的脱氢酶活性没有影响。可能在新替米星作用下，巨大芽孢杆菌原生质体琥珀酸脱氢酶受到抑制是由于抗生素使原生质体膜发生了显著的结构变化，导致膜裂解，而非对酶的直接作用。新替米星对耐该抗生素的大肠杆菌球状体脱氢酶活性几乎没有影响，也不诱导其裂解。大肠杆菌对新替米星的抗性一定不是与抗生素不可渗透的细胞壁的存在有关，而是与膜细胞质的特殊性质有关。
