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t(8;21)AML patients with RUNX1e6::RUNX1T19a splice variant have poor prognosis.

作者信息

Fan Yuying, Chen Lanhui, Liu Sijin, Dang Jinwen, Chang Jianmei, Guo Caifeng, Xu Yang, Guo Wenzheng, Wang Hongwei, Tan Yanhong

机构信息

Institute of Hematology, The Second Hospital of Shanxi Medical University, Taiyuan, 030001, China.

出版信息

Ann Hematol. 2025 Aug 11. doi: 10.1007/s00277-025-06545-1.

DOI:10.1007/s00277-025-06545-1
PMID:40784929
Abstract
摘要

相似文献

1
t(8;21)AML patients with RUNX1e6::RUNX1T19a splice variant have poor prognosis.具有RUNX1e6::RUNX1T19a剪接变体的t(8;21)急性髓系白血病患者预后较差。
Ann Hematol. 2025 Aug 11. doi: 10.1007/s00277-025-06545-1.
2
Persistent altered fusion transcript splicing identifies RUNX1-RUNX1T1+ AML patients likely to relapse.持续改变的融合转录剪接鉴定出 RUNX1-RUNX1T1+AML 患者可能复发。
Eur J Haematol. 2010 Feb 1;84(2):128-32. doi: 10.1111/j.1600-0609.2009.01371.x. Epub 2009 Nov 5.
3
Single-cell RNA-seq reveals novel immune-associated biomarkers for predicting prognosis in AML patients with RUNX1::RUNX1T1.单细胞 RNA 测序揭示了与 RUNX1::RUNX1T1 相关的新型免疫相关生物标志物，可用于预测 AML 患者的预后。
Int Immunopharmacol. 2023 Dec;125(Pt B):111178. doi: 10.1016/j.intimp.2023.111178. Epub 2023 Nov 9.
4
[Expression of CD19 and CD56 in AML Patients with RUNX1-RUNX1T1 Mutation and Its Clinical Significance].[RUNX1-RUNX1T1突变的急性髓系白血病患者CD19和CD56的表达及其临床意义]
Zhongguo Shi Yan Xue Ye Xue Za Zhi. 2018 Jun;26(3):727-732. doi: 10.7534/j.issn.1009-2137.2018.03.016.
5
[Clinical Prognostic Factors Analysis of Initially Treated AML Children with t(8;21)/RUNX1-RUNX1T1].初治伴t(8;21)/RUNX1-RUNX1T1的儿童急性髓系白血病临床预后因素分析
Zhongguo Shi Yan Xue Ye Xue Za Zhi. 2020 Oct;28(5):1510-1515. doi: 10.19746/j.cnki.issn.1009-2137.2020.05.014.
6
WT1 together with RUNX1::RUNX1T1 targets DUSP6 to dampen ERK activity in acute myeloid leukaemia.WT1 与 RUNX1::RUNX1T1 共同作用于 DUSP6，以抑制急性髓系白血病中的 ERK 活性。
Br J Haematol. 2024 Nov;205(5):1848-1859. doi: 10.1111/bjh.19721. Epub 2024 Aug 27.
7
Combination of eriocalyxin B and homoharringtonine exerts synergistic anti-tumor effects against t(8;21) AML.联合依利替康 B 和高三尖杉酯碱对 t(8;21) AML 发挥协同抗肿瘤作用。
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8
High number of additional genetic lesions in acute myeloid leukemia with t(8;21)/RUNX1-RUNX1T1: frequency and impact on clinical outcome.急性髓系白血病伴 t(8;21)/RUNX1-RUNX1T1 患者中存在大量额外的遗传病变：频率及对临床结局的影响。
Leukemia. 2014 Jul;28(7):1449-58. doi: 10.1038/leu.2014.4. Epub 2014 Jan 9.
9
A minicircuitry of microRNA-9-1 and RUNX1-RUNX1T1 contributes to leukemogenesis in t(8;21) acute myeloid leukemia.微小RNA-9-1与RUNX1-RUNX1T1的微回路促进了t(8;21)急性髓系白血病的白血病发生。
Int J Cancer. 2017 Feb 1;140(3):653-661. doi: 10.1002/ijc.30481. Epub 2016 Nov 10.
10
[Related Factors Affecting Long-term Prognosis of AML Children with Positive RUNX1-RUNX1T1].[影响RUNX1-RUNX1T1阳性儿童急性髓系白血病长期预后的相关因素]
Zhongguo Shi Yan Xue Ye Xue Za Zhi. 2019 Dec;27(6):1767-1773. doi: 10.19746/j.cnki.issn.1009-2137.2019.06.010.

本文引用的文献

1
Single-cell RNA sequencing of a new transgenic t(8;21) preleukemia mouse model reveals regulatory networks promoting leukemic transformation.单细胞 RNA 测序新型 t(8;21) 白血病前转基因小鼠模型揭示了促进白血病转化的调控网络。
Leukemia. 2024 Jan;38(1):31-44. doi: 10.1038/s41375-023-02063-z. Epub 2023 Oct 14.
2
A direct comparison between AML1-ETO and ETO2-GLIS2 leukemia fusion proteins reveals context-dependent binding and regulation of target genes and opposite functions in cell differentiation.AML1-ETO与ETO2-GLIS2白血病融合蛋白之间的直接比较揭示了靶基因的上下文依赖性结合与调控以及在细胞分化中的相反功能。
Front Cell Dev Biol. 2022 Sep 7;10:992714. doi: 10.3389/fcell.2022.992714. eCollection 2022.
3
Biophysical and pharmacokinetic characterization of a small-molecule inhibitor of RUNX1/ETO tetramerization with anti-leukemic effects.
具有抗白血病作用的 RUNX1/ETO 四聚体小分子抑制剂的物理化学和药代动力学特征。
Sci Rep. 2022 Aug 19;12(1):14158. doi: 10.1038/s41598-022-17913-6.
4
Correction to: Combining the differentiating effect of panobinostat with the apoptotic effect of arsenic trioxide leads to significant survival benefit in a model of t(8;21) acute myeloid leukemia.对《帕比司他的分化作用与三氧化二砷的凋亡作用相结合可在t(8;21)急性髓系白血病模型中带来显著生存获益》一文的更正
Clin Epigenetics. 2020 Nov 18;12(1):178. doi: 10.1186/s13148-020-00964-9.
5
An update on the molecular pathogenesis and potential therapeutic targeting of AML with t(8;21)(q22;q22.1);RUNX1-RUNX1T1.AML 伴 t(8;21)(q22;q22.1);RUNX1-RUNX1T1 的分子发病机制及潜在治疗靶点的研究进展。
Blood Adv. 2020 Jan 14;4(1):229-238. doi: 10.1182/bloodadvances.2019000168.
6
The clinical mutatome of core binding factor leukemia.核心结合因子白血病的临床突变组学。
Leukemia. 2020 Jun;34(6):1553-1562. doi: 10.1038/s41375-019-0697-0. Epub 2020 Jan 2.
7
Functional and clinical characterization of the alternatively spliced isoform AML1-ETO9a in adult patients with translocation t(8;21)(q22;q22.1) acute myeloid leukemia (AML).8号和21号染色体易位（t(8;21)(q22;q22.1)）的成年急性髓系白血病（AML）患者中可变剪接异构体AML1-ETO9a的功能和临床特征
Leukemia. 2020 Feb;34(2):630-634. doi: 10.1038/s41375-019-0551-4. Epub 2019 Aug 28.
8
Clinical Relevance of RUNX1 and CBFB Alterations in Acute Myeloid Leukemia and Other Hematological Disorders.RUNX1和CBFB改变在急性髓系白血病及其他血液系统疾病中的临床相关性
Adv Exp Med Biol. 2017;962:175-199. doi: 10.1007/978-981-10-3233-2_12.
9
JAK inhibitors suppress t(8;21) fusion protein-induced leukemia.JAK 抑制剂抑制 t(8;21)融合蛋白诱导的白血病。
Leukemia. 2013 Dec;27(12):2272-9. doi: 10.1038/leu.2013.197. Epub 2013 Jul 1.
10
A novel recurrent AML1-ETO fusion: tight in vivo association with BCR-ABL1.一种新型复发性AML1-ETO融合基因：在体内与BCR-ABL1紧密相关。
Leukemia. 2013 Jun;27(6):1397-400. doi: 10.1038/leu.2013.53. Epub 2013 Feb 21.