具有RUNX1e6::RUNX1T19a剪接变体的t(8;21)急性髓系白血病患者预后较差。 - Suppr

t(8;21)AML patients with RUNX1e6::RUNX1T19a splice variant have poor prognosis.

作者信息

Fan Yuying, Chen Lanhui, Liu Sijin, Dang Jinwen, Chang Jianmei, Guo Caifeng, Xu Yang, Guo Wenzheng, Wang Hongwei, Tan Yanhong

机构信息

Institute of Hematology, The Second Hospital of Shanxi Medical University, Taiyuan, 030001, China.

出版信息

Ann Hematol. 2025 Aug 11. doi: 10.1007/s00277-025-06545-1.

DOI:10.1007/s00277-025-06545-1

PMID:40784929

Abstract

摘要

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t(8;21)AML patients with RUNX1e6::RUNX1T19a splice variant have poor prognosis.

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A direct comparison between AML1-ETO and ETO2-GLIS2 leukemia fusion proteins reveals context-dependent binding and regulation of target genes and opposite functions in cell differentiation.

Front Cell Dev Biol. 2022 Sep 7;10:992714. doi: 10.3389/fcell.2022.992714. eCollection 2022.

Biophysical and pharmacokinetic characterization of a small-molecule inhibitor of RUNX1/ETO tetramerization with anti-leukemic effects.

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t(8;21)AML patients with RUNX1e6::RUNX1T19a splice variant have poor prognosis.

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t(8;21)AML patients with RUNX1e6::RUNX1T19a splice variant have poor prognosis.

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