Huang Shih-Ting, Chuang Ya-Wen, Chiu Chih-Wei, Sun Kuo-Ting, Chang Shih-Sheng, Wang I-Kuan, Lee Brain K, Kung Shiang-Cheng, Li Chi-Yuan, Yu Tung-Min
Division of Nephrology, Taichung Veterans General Hospital, Taiwan Boulevard Sect. 4, Taichung, 40705, Taiwan.
Department of Post-Baccalaureate Medicine, College of Medicine, National Chung Hsing University, Taichung, Taiwan.
Sci Rep. 2025 Aug 10;15(1):29275. doi: 10.1038/s41598-025-15169-4.
Data on liver issues including liver cirrhosis, hepatocellular carcinoma, and hepatic failure in renal transplant patients with HCV infection are scarce. In the present study, we conducted a large-scale population-based analysis to investigate the long-term outcomes of renal recipients with HCV infection. Propensity score matching with a ratio of 1:1 was applied. A total of 6,473renal recipients with HCV infection in case group were enrolled after PSM. Our findings showed that subjects with HCV infection in kidney transplant had significantly higher risk of hepatoma, cirrhosis, hepatic failure, and overall hepatic disease than those without HCV infection. (hepatoma: HR: 8.957; 95% CI: 5.324-15.069; cirrhosis: HR: 5.378; 95% CI: 4.363-6.631; hepatic failure: HR: 3.258; 95% CI: 2.527-4.200; overall hepatic disease: HR: 4.128; 95% CI: 3.428-4.971). In the present study, our findings show that renal recipients with HCV infection is significantly associated with a remarkably high risk of hepatic complications post-kidney transplantation.
关于丙型肝炎病毒（HCV）感染的肾移植患者出现肝硬化、肝细胞癌和肝衰竭等肝脏问题的数据十分匮乏。在本研究中，我们进行了一项基于大规模人群的分析，以调查HCV感染的肾移植受者的长期预后。采用了1:1的倾向评分匹配法。倾向评分匹配后，病例组共纳入6473例HCV感染的肾移植受者。我们的研究结果表明，肾移植中HCV感染的受试者发生肝癌、肝硬化、肝衰竭及总体肝脏疾病的风险显著高于未感染HCV的受试者。（肝癌：风险比（HR）：8.957；95%置信区间（CI）：5.324 - 15.069；肝硬化：HR：5.378；95% CI：4.363 - 6.631；肝衰竭：HR：3.258；95% CI：2.527 - 4.200；总体肝脏疾病：HR：4.128；95% CI：3.428 - 4.971）。在本研究中，我们的研究结果表明，HCV感染的肾移植受者与肾移植后肝脏并发症的高风险显著相关。
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