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“我无法抬起我的双腿”:一个导向抗合成酶综合征诊断的有趣病例表现

"I Can't Lift My Legs": An Interesting Presentation Leading to the Diagnosis of Anti-synthetase Syndrome.

作者信息

Hussain Javed A, Antony Chinju, Thirunavukarasu Madan, Yasin Athar

机构信息

Emergency Medicine, Peterborough City Hospital, Peterborough, GBR.

出版信息

Cureus. 2025 Jul 8;17(7):e87570. doi: 10.7759/cureus.87570. eCollection 2025 Jul.

Abstract

Anti-synthetase syndrome (ASS) is an autoimmune disorder that often manifests through lung involvement such as interstitial lung disease, inflammation of the muscles, and symptoms affecting the joints, including pain or arthritis. Identifying ASS involves a multidisciplinary effort between rheumatologists and lung specialists, using a combination of blood work, imaging techniques, and, in some cases, biopsies of muscle or lung tissue to reach a diagnosis. Treatment usually involves corticosteroids along with other immunosuppressive medications. In this case, we explore the diagnostic journey of a 37-year-old patient who initially presented with an unusual complaint: difficulty lifting his leg, alongside a range of other symptoms. This case highlights the complexity and challenges involved in identifying anti-synthetase syndrome.

摘要

抗合成酶综合征(ASS)是一种自身免疫性疾病,常表现为肺部受累,如间质性肺病、肌肉炎症以及影响关节的症状,包括疼痛或关节炎。抗合成酶综合征的诊断需要风湿病学家和肺部专家的多学科协作,结合血液检查、成像技术,在某些情况下还需要进行肌肉或肺组织活检才能确诊。治疗通常包括使用皮质类固醇以及其他免疫抑制药物。在本病例中,我们探讨了一名37岁患者的诊断过程,该患者最初出现了一个不寻常的症状:抬腿困难,同时伴有一系列其他症状。这个病例凸显了抗合成酶综合征诊断过程中的复杂性和挑战。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/502c/12334074/610a53b1d8f4/cureus-0017-00000087570-i01.jpg

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