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一例罕见的尿道腺癌病例。

A Rare Case of Adenocarcinoma of the Urethra.

作者信息

Shafiq Muhammad Waqas, Ahmad Taha, Naseem Rabbya, Asif Aisha, Mir Khurram

机构信息

Surgical Oncology, Shaukat Khanum Memorial Cancer Hospital and Research Centre, Lahore, PAK.

General Surgery, Shaukat Khanum Memorial Cancer Hospital and Research Centre, Lahore, PAK.

出版信息

Cureus. 2025 Jul 9;17(7):e87610. doi: 10.7759/cureus.87610. eCollection 2025 Jul.

DOI:10.7759/cureus.87610
PMID:40786309
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12333902/
Abstract

Primary urethral adenocarcinoma is a rare and aggressive subtype of primary urethral carcinoma. We report the case of a 37-year-old man with a three-month history of painless hematuria. An initial superficial biopsy revealed poorly differentiated carcinoma with squamous features, but further histopathology after transurethral resection confirmed high-grade anterior urethral adenocarcinoma (T1 N0 Mx) without regional or distant metastasis. After multidisciplinary discussion, urethrectomy with perineal urethrostomy was recommended; however, the patient declined surgery and chose systemic cisplatin-gemcitabine chemotherapy instead.

摘要

原发性尿道腺癌是原发性尿道癌中一种罕见且侵袭性强的亚型。我们报告了一例37岁男性患者，有三个月无痛性血尿病史。最初的浅表活检显示为具有鳞状特征的低分化癌，但经尿道切除术后的进一步组织病理学检查证实为高级别前尿道腺癌（T1 N0 Mx），无区域或远处转移。经过多学科讨论，建议行尿道切除术与会阴尿道造口术；然而，患者拒绝手术，选择了全身顺铂-吉西他滨化疗。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cd00/12333902/18b94e67d0f8/cureus-0017-00000087610-i03.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cd00/12333902/f17193f811eb/cureus-0017-00000087610-i01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cd00/12333902/0290a7514320/cureus-0017-00000087610-i02.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cd00/12333902/18b94e67d0f8/cureus-0017-00000087610-i03.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cd00/12333902/f17193f811eb/cureus-0017-00000087610-i01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cd00/12333902/0290a7514320/cureus-0017-00000087610-i02.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cd00/12333902/18b94e67d0f8/cureus-0017-00000087610-i03.jpg

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本文引用的文献

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Medicine (Baltimore). 2025 May 16;104(20):e42329. doi: 10.1097/MD.0000000000042329.
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Female primary urethral carcinoma: A rare case report.女性原发性尿道癌：一例罕见病例报告。
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Squamous differentiation is a potential biomarker predicting tumor progression in patients treated with pembrolizumab for urothelial carcinoma.鳞状分化是预测接受派姆单抗治疗的尿路上皮癌患者肿瘤进展的潜在生物标志物。
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Primary Adenocarcinoma of the Urethra: A Case Report and Review of the Literature.原发性尿道腺癌：一例报告并文献复习
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Cancer. 2011 Jun 1;117(11):2426-34. doi: 10.1002/cncr.25787. Epub 2010 Dec 14.
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Urethral cancer.尿道癌。
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Rare cancers are not so rare: the rare cancer burden in Europe.罕见癌症并不罕见：欧洲的罕见癌症负担。
Eur J Cancer. 2011 Nov;47(17):2493-511. doi: 10.1016/j.ejca.2011.08.008. Epub 2011 Oct 25.
10
Incidence of primary urethral carcinoma in the United States.美国原发性尿道癌的发病率。
Urology. 2006 Dec;68(6):1164-8. doi: 10.1016/j.urology.2006.08.1057. Epub 2006 Dec 4.