A Rare Case of Adenocarcinoma of the Urethra.

Primary urethral adenocarcinoma is a rare and aggressive subtype of primary urethral carcinoma. We report the case of a 37-year-old man with a three-month history of painless hematuria. An initial superficial biopsy revealed poorly differentiated carcinoma with squamous features, but further histopathology after transurethral resection confirmed high-grade anterior urethral adenocarcinoma (T1 N0 Mx) without regional or distant metastasis. After multidisciplinary discussion, urethrectomy with perineal urethrostomy was recommended; however, the patient declined surgery and chose systemic cisplatin-gemcitabine chemotherapy instead.