Shabir Muhammad, Khan Muhammad Yasin, Khan Muhammad Younas, Ali Murad, Syed Rahman, Khan Ameer Afzal, Khan Anfal, Syed Fazal, Idrees Mohammad, Tariq Muhammad
Orthopaedics, Saidu Group of Teaching Hospitals, Swat, PAK.
Internal Medicine, Swat Medical College, Swat, PAK.
Cureus. 2025 Jul 11;17(7):e87721. doi: 10.7759/cureus.87721. eCollection 2025 Jul.
Osteoporosis remains a significant contributor to illness and death among postmenopausal women, primarily due to complications from fractures. This study examined national trends and disparities in osteoporosis-related mortality over a 24-year period.
Mortality records of postmenopausal women from 1999 to 2023 were analyzed using the Centers for Disease Control and Prevention Wide-Ranging Online Data for Epidemiologic Research (CDC WONDER) database to assess osteoporosis-related deaths. Age-adjusted mortality rates (AAMRs) were calculated and examined across time, demographic groups, geographic regions, and fracture involvement. Statistical trend analysis was used to evaluate changes in mortality patterns over time.
A total of 232,877 osteoporosis-related deaths were recorded. The overall AAMR declined from 29.35 in 1999 to 12.00 in 2023 (average annual percent change (AAPC): -3.75%; 95% CI: -4.71 to -2.77; p < 0.000001). Mortality due to osteoporosis with pathological fracture showed a sharper decline (AAPC: -5.14%) compared to osteoporosis without fracture (AAPC: -3.62%). White women had the highest AAMRs throughout, though all racial/ethnic groups experienced significant reductions. Regional analysis revealed the highest mortality rates in the Midwest and West, with Vermont reporting the highest state-level AAMR (74.97). Recent years (2018-2021) showed non-significant increases in mortality across subgroups, which may be associated with healthcare disruptions during COVID-19.
Osteoporosis-related mortality among postmenopausal women significantly declined over the past 25 years, reflecting advances in diagnosis, treatment, and prevention. However, persistent racial, geographic, and fracture-related disparities underscore the need for targeted public health interventions and equitable access to osteoporosis care.
骨质疏松症仍然是绝经后女性患病和死亡的一个重要因素，主要是由于骨折引发的并发症。本研究调查了24年间骨质疏松症相关死亡率的全国趋势和差异。
利用美国疾病控制与预防中心的广泛在线流行病学研究数据（CDC WONDER）数据库分析1999年至2023年绝经后女性的死亡记录，以评估与骨质疏松症相关的死亡情况。计算并检查了年龄调整死亡率（AAMR）在不同时间、人口群体、地理区域和骨折情况方面的变化。采用统计趋势分析来评估死亡率模式随时间的变化。
共记录了232,877例与骨质疏松症相关的死亡。总体AAMR从1999年的29.35降至2023年的12.00（年均百分比变化（AAPC）：-3.75%；95%置信区间：-4.71至-2.77；p<0.000001）。与无骨折的骨质疏松症相比，病理性骨折导致的骨质疏松症死亡率下降更为明显（AAPC：-5.14%）。白人女性的AAMR始终最高，不过所有种族/族裔群体的死亡率都有显著下降。区域分析显示中西部和西部的死亡率最高，佛蒙特州报告的州级AAMR最高（74.97）。近年来（2018 - 2021年），各亚组的死亡率出现了不显著的上升，这可能与新冠疫情期间医疗服务中断有关。
在过去25年中，绝经后女性与骨质疏松症相关的死亡率显著下降，这反映了诊断、治疗和预防方面的进展。然而，持续存在的种族、地理和骨折相关差异凸显了有针对性的公共卫生干预措施以及公平获得骨质疏松症护理的必要性。
